Molecular Fingerprint Imaging to Identify Dental Caries Using Raman Spectroscopy

被引：17

作者：

Miyamoto, Nao ^{[1
,2
]}

Adachi, Tetsuya ^{[1
,3
]}

Boschetto, Francesco ^{[1
,4
,5
]}

Zanocco, Matteo ^{[4
,5
]}

Yamamoto, Toshiro ^{[1
]}

Marin, Elia ^{[1
,4
]}

Somekawa, Shota ^{[6
]}

Ashida, Ryutaro ^{[6
]}

Zhu, Wenliang ^{[4
]}

Kanamura, Narisato ^{[1
]}

Nishimura, Ichiro ^{[7
,8
]}

Pezzotti, Giuseppe ^{[4
,5
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Dent Med, Kamigyo Ku, Kyoto 6028566, Japan

[2] Kyoto Prefectural Univ Med, Infect Dis, Kamigyo Ku, 465 Kajii Cho, Kyoto 6028566, Japan

[3] Kyoto Prefectural Rehabil Hosp Mentally & Physica, Dent, Kyoto 6100113, Japan

[4] Kyoto Inst Technol, Ceram Phys Lab, Sakyo Ku, Kyoto 6068585, Japan

[5] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Immunol, Kamigyo Ku, 465 Kajii Cho, Kyoto 6028566, Japan

[6] ShinSei Co Ltd, Kyoto 6110033, Japan

[7] Univ Calif Los Angeles, Jane & Jerry Weintraub Ctr Re Construct Biotechno, Div Oral Biol & Med, Sch Dent, Los Angeles, CA 90095 USA

[8] Univ Calif Los Angeles, Jane & Jerry Weintraub Ctr Reconstruct Biotechnol, Div Adv Prosthodont, Sch Dent, Los Angeles, CA 90095 USA

来源：

MATERIALS | 2020年 / 13卷 / 21期

关键词：

dentistry; Raman spectroscopy; caries; laser fluorescence; QUANTITATIVE CRYSTALLOGRAPHIC ANALYSES; VIBRATIONAL ALGORITHMS; PERFORMANCE; TRANSILLUMINATION; DIAGNODENT; ENAMEL; RADIOGRAPHY; EXPOSURE; SYSTEM;

D O I：

10.3390/ma13214900

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Tooth loss impairs mastication, deglutition and esthetics and affects systemic health through nutritional deficiency, weight loss, muscle weakness, delayed wound healing, and bone fragility. Approximately 90% of tooth loss is due to dental caries and periodontal disease. Accordingly, early treatment of dental caries is essential to maintaining quality of life. To date, the clinical diagnosis of dental caries has been based on each dentist's subjective assessment, but this visual method lacks objectivity. To improve diagnostic ability, highly sensitive quantitative methods have been developed for the diagnosis and prevention of dental caries and are gradually becoming a mandatory item in modern dentistry. High-resolution Raman spectroscopy is a suitable tool for recognizing the subtle structural changes that occur in dental enamel in already developed or, more importantly, incipient dental caries. Raman analysis could soon emerge as a breakthrough in dentistry because of its high diagnostic sensitivity. In this study, we build upon our previous findings in a new analysis of dental caries using Raman spectroscopy imaging and discuss the possibility of using Raman photonic imaging in support of objective diagnostics in dentistry. Our findings support the Raman method of caries detection in comparison with other conventional or new approaches.

引用

页码：1 / 15

页数：15

共 33 条

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