Native-like Env trimers as a platform for HIV-1 vaccine design

被引：195

作者：

Sanders, Rogier W. ^{[1
,2
]}

Moore, John P. ^{[1
]}

机构：

[1] Cornell Univ, Dept Microbiol & Immunol, Weill Med Coll, New York, NY 10021 USA

[2] Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, Amsterdam, Netherlands

来源：

IMMUNOLOGICAL REVIEWS | 2017年 / 275卷 / 01期

基金：

欧洲研究理事会;

关键词：

Env trimers; HIV-1; vaccines; neutralizing antibodies; IMMUNODEFICIENCY-VIRUS TYPE-1; ENVELOPE GLYCOPROTEIN TRIMERS; BROADLY NEUTRALIZING ANTIBODIES; CRYO-EM STRUCTURE; B-CELL RECEPTORS; CRYSTAL-STRUCTURE; AFFINITY MATURATION; GP140; TRIMERS; RECOMBINANT GLYCOPROTEIN-120; PROTEOLYTICALLY MATURE;

D O I：

10.1111/imr.12481

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe the development and potential use of various designs of recombinant HIV-1 envelope glycoprotein trimers that mimic the structure of the virion-associated spike, which is the target for neutralizing antibodies. The goal of trimer development programs is to induce broadly neutralizing antibodies with the potential to intervene against multiple circulating HIV-1 strains. Among the topics we address are the designs of various constructs; how native-like trimers can be produced and purified; the properties of such trimers in vitro and their immunogenicity in various animals; and the immunization strategies that may lead to the eventual elicitation of broadly neutralizing antibodies. In summary, native-like trimers are a now a platform for structure- and immunology-based design improvements that could eventually yield immunogens of practical value for solving the long-standing HIV-1 vaccine problem.

引用

页码：161 / 182

页数：22

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