Anti-inflammatory activity of four Bolivian Baccharis species (Compositae)

被引：38
作者：
Abad, M [1 ]
Bessa, AL
Ballarin, B
Aragón, O
Gonzales, E
Bermejo, P
机构：
[1] Univ Complutense, Fac Pharm, Dept Pharmacol, E-28040 Madrid, Spain
[2] Univ San Andres, Inst Invest Farmacobioquim, La Paz, Bolivia
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2006年 / 103卷 / 03期
关键词：
Baccharis; PGE(2); LTC4; NO; TNF-alpha;
D O I：
10.1016/j.jep.2005.08.024
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Hexanic, dichloromethanic, ethanolic and aqueous extracts from Baccharis obtusifolia HBK, Baccharis latifolia (R. et P.) Pers., Baccharis pentlandii D.C. and Baccharis subulata Wedd., plants used in the traditional medicine of South America have been studied for their in vitro anti-inflammatory activity in cellular systems. Calcium ionophore A23187-stimulated mouse peritoneal macrophages were validated as a source of cyclooxygenase-1 (COX-1) (prostaglandin E-2, PGE(2)) and 5-lipoxygenase (5-LOX) (leukotriene C-4, LTC4) and mouse peritoneal macrophages stimulated with Escherichia coli lipopolysaccharide (LPS) were used for testing cyclooxygenase-2 (COX-2) (PGE(2)), nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) activity. Most of the extracts tested were active in all assays. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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页码：338 / 344
页数：7
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