Oxysterols: Influence on plasma membrane rafts microdomains and development of ocular diseases

被引：18
作者：
Filomenko, Rodolphe [1 ,2 ,3 ]
Fourgeux, Cynthia [1 ,2 ,3 ]
Bretillon, Lionel [1 ,2 ,3 ]
Gambert-Nicot, Segolene [1 ,2 ,3 ,4 ]
机构：
[1] INRA, Ctr Sci Gout & Alimentat Equipe Ceil Nutr & Signa, UMR1324, F-21000 Dijon, France
[2] CNRS, Ctr Sci Gout & Alimentat, UMR6265, F-21000 Dijon, France
[3] Univ Bourgogne, Ctr Sci Gout & Alimentat, F-21000 Dijon, France
[4] CHU Dijon, Serv Biochim Clin, F-21000 Dijon, France
来源：
STEROIDS | 2015年 / 99卷
关键词：
Oxysterols; Lipid rafts; Retinopathy; Cholesterol; CYP46A1; LIVER X RECEPTOR; CENTRAL-NERVOUS-SYSTEM; LIPOPROTEIN-LIKE PARTICLES; BLOOD-BRAIN-BARRIER; ALZHEIMERS-DISEASE; LIPID RAFTS; MACULAR DEGENERATION; IN-VIVO; CHOLESTEROL-24S-HYDROXYLASE CYP46A1; NEURODEGENERATIVE DISEASES;
D O I：
10.1016/j.steroids.2015.02.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxidation of cholesterol into oxysterols is a major way of elimination of cholesterol from the liver and extrahepatic tissues, including the brain and the retina. Oxysterols are involved in various cellular processes. Numerous links have been established between oxysterols and several disorders such as neurodegenerative pathologies, retinopathies and atherosclerosis. Different components of the lipid layer such as sphingolipids, sterols and proteins participate to membrane fluidity and forme lipid rafts microdomains. Few data are available on the links between lipids rafts and oxysterols. The purpose of this review is to suggest the potential role of lipid rafts microdomains in the development of retinopathies with special emphasis and opening perspectives of their interactions with oxysterols. Actually cholesterol oxidation mechanism may have deleterious effect on its ability to support rafts formation. This review suggest that the effect of oxysterols of lipid rafts would probably depend on the oxysterol molecule and cell type. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：259 / 265
页数：7
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