Severe drug-induced hypersensitivity syndrome with a shared HLA-B allele

被引：14

作者：

Harding, Damian J. ^{[1
]}

Subramaniam, Kavitha ^{[1
]}

MacQuillan, Gerry ^{[2
]}

Davis, Joshua ^{[3
,4
]}

Nolan, David ^{[5
]}

机构：

[1] Sir Charles Gairdner Hosp, Dept Hepatol, Perth, WA 6000, Australia

[2] Univ Western Australia, Dept Hepatol, Sch Med & Pharmacol, Perth, WA 6009, Australia

[3] Royal Darwin Hosp, Darwin, NT, Australia

[4] Menzies Sch Hlth Res, Darwin, NT, Australia

[5] Royal Perth Hosp, Dept Immunol, Perth, WA, Australia

来源：

MEDICAL JOURNAL OF AUSTRALIA | 2012年 / 197卷 / 07期

关键词：

STEVENS-JOHNSON SYNDROME; CLINICAL-FEATURES;

D O I：

10.5694/mja12.10477

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe the first reported cases of phenytoin-related drug-induced hypersensitivity syndrome in unrelated Indigenous Australians with the same HLA-B*56:02 allele. These patients shared common clinical and pathological features, and all three were found to have the otherwise rare HLA-B which might represent a novel genetic susceptibility factor for this syndrome.

引用

页码：411 / 413

页数：3

共 11 条

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