Hypolipemic and antioxidant activities from Tamarindus indica L. pulp fruit extract in hypercholesterolemic hamsters

被引:120
作者
Martinello, F.
Soares, S. M.
Franco, J. J.
Santos, A. C.
Sugohara, A.
Garcia, S. B.
Curti, C.
Uyemura, S. A.
机构
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, Brazil
[2] Univ Sao Paulo, Dept Quim & Fis, BR-14040903 Ribeirao Preto, SP, Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Patol, BR-14040903 Ribeirao Preto, SP, Brazil
[4] Univ Estadual Paulista, Dept Zootecn, Fac Ciencias Agrarias & Vet, BR-14884900 Jaboticabal, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
tamarind; Tamarindus indica L; hypercholesterolemic hamster; antioxidant activity; free radical; atherosclerosis;
D O I
10.1016/j.fct.2005.10.011
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Dietary modifications may significantly reduce cardiovascular disease (CVD) risk factors, including cholesterol and atherosclerosis. The present study addressed the effects of the crude extract from the pulp fruit of Tamarindus indica L. on lipid serum levels and early atherosclerotic lesions in hypercholesterolemic hamsters in vivo, and the extract's antioxidant action, in vitro. Animals were fed on either chow or atherogenic diet during 10 weeks and concomitantly received either water or T indica L. extract for drinking. Treatment of hypercholesterolemic hamsters with the T. indica pulp fruit extract (5%) led to a decrease in the levels of serum total cholesterol (50%), non-HDL cholesterol (73%) and triglyceride (60%), and to an increase of high-density lipoprotein (HDL) cholesterol levels (61%). In vitro, the extract presented radical scavenging ability, as assessed by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide radicals assays, and led to decreased lipid peroxidation in serum, as assessed by the thiobarbituric acid reactive substances (TBARS) assay. In vivo, the extract improved the efficiency of the antioxidant defense system, as assessed by the superoxide dismutase, catalase and glutathione peroxidase activities. Together these results indicate the potential of tamarind extracts in diminishing the risk of atherosclerosis development in humans. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:810 / 818
页数:9
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