Somatostatin modulates LTP in hippocampal CA1 pyramidal neurons: Differential activation conditions in apical and basal dendrites

被引：7

作者：

Fan, Wei ^{[1
]}

Fu, Ting ^{[2
]}

机构：

[1] Leibniz Inst Neurobiol, D-39118 Magdeburg, Germany

[2] Otto von Guericke Univ, Inst Mol Biol & Med Chem, Magdeburg, Germany

来源：

NEUROSCIENCE LETTERS | 2014年 / 561卷

关键词：

Hippocampus; Long-term potentiation; Somatostatin; Apical dendrite; Basal dendrite; Rat; LONG-TERM POTENTIATION; CENTRAL-NERVOUS-SYSTEM; MOSSY FIBER-CA3 SYSTEM; RAT-BRAIN; IMMUNOHISTOCHEMICAL LOCALIZATION; GUINEA-PIG; INTERNEURON-DIVERSITY; SYNAPTIC-TRANSMISSION; STRATUM-ORIENS; LATE-PHASE;

D O I：

10.1016/j.neulet.2013.12.025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The cyclic neuropeptide, somatostatin, is widely expressed in mammalian brain and modulates hormone secretion and neurotransmission. The long-term potentiation (LTP) at Schaffer collateral synapses onto hippocampal CA1 pyramidal neurons has been intensively studied as a cellular model of learning and memory. The apical (stratum radiatum) and basal dendrites (stratum oriens) of CA1 pyramidal neurons differ in LTP induction and maintenance. Here the role of somatostatin in the modulation of LTP was investigated in rat hippocampus. Our results show that somatostatin enhances LTP in apical and basal dendrites. However, the activation conditions of the somatostatin system are different in these two compartments. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1 / 6

页数：6

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