Commentary: IL-4 and IL-13 receptors and signaling

被引：239
|
作者：
McCormick, Sarah M. [1 ]
Heller, Nicola M. [1 ,2 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Div Allergy & Clin Immunol, Baltimore, MD 21205 USA
来源：
CYTOKINE | 2015年 / 75卷 / 01期
关键词：
Interleukin-4; Interleukin-13; Singling; Regulation; Receptor; TYROSINE-PHOSPHATASE SHP-1; ALLERGIC AIRWAY INFLAMMATION; SINGLE-NUCLEOTIDE POLYMORPHISM; INTERLEUKIN (IL)-13 RESPONSES; MULTIPLE-SCLEROSIS PATIENTS; IN-VIVO; RHEUMATOID-ARTHRITIS; OXIDATIVE STRESS; GENE-EXPRESSION; UP-REGULATION;
D O I：
10.1016/j.cyto.2015.05.023
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interleukin (IL)-4 and IL-13 were discovered approximately 30 years ago and were immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 and their receptors in normal gestation, fetal development and neurological function and in the pathogenesis of cancer and fibrosis have been appreciated. Studying IL-4/-13 and their receptors has revealed important clues about cytokine biology and led to the development of numerous experimental therapeutics. Here we aim to highlight new discoveries and consolidate concepts in the field of IL-4 and IL-13 structure, receptor regulation, signaling and experimental therapeutics. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：38 / 50
页数：13
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