Nesfatin-1 in advanced lung cancer patients with weight loss

被引：18

作者：

Cetinkaya, Hakki ^{[1
]}

Karagoz, Bulent ^{[2
]}

Bilgi, Oguz ^{[2
]}

Ozgun, Alpaslan ^{[2
]}

Tuncel, Tolga ^{[2
]}

Emirzeoglu, Levent ^{[2
]}

Top, Cihan ^{[3
]}

Kandemir, Emin Gokhan ^{[2
]}

机构：

[1] Gulhane Mil Med Acad, Dept Nephrol, Ankara, Turkey

[2] Gulhane Mil Med Acad, Haydarpasa Training Hosp, Dept Med Oncol, Ankara, Turkey

[3] Gulhane Mil Med Acad, Haydarpasa Training Hosp, Dept Internal Med, Ankara, Turkey

来源：

REGULATORY PEPTIDES | 2013年 / 181卷

关键词：

Nesfatin; Lung cancer; Weight loss; Cachexia; GHRELIN; LEPTIN; LEVEL;

D O I：

10.1016/j.regpep.2012.11.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The cachexia occurs frequently in lung cancer patients. Among appetite regulatory peptides, alteration of expressions of leptin and ghrelin is demonstrated in cachectic cancer patients, but nesfatin-1 has not been yet studied in cancer. We investigated serum nesfatin-1 level in advanced lung cancer patients. Forty-one lung cancer patients and 24 healthy subjects were included to the study. Nesfatin-1 serum levels were analyzed by ELISA kit. Serum nesfatin-1 levels were lower in lung cancer patients than in healthy subjects (0.52+0.19 ng/ml vs 0.75 +/- 0.23 ng/ml; p<0.001). In lung cancer patients with weight loss, nesfatin-1 levels were decreased compared to the patients without weight loss (0.44+0.16 ng/ml vs 0.63 +/- 0.18 ng/ml; p<0.001). Whereas, there were no any difference between patients without weight loss and control subjects (0.63+0.18 ng/ml vs 0.75+0.23 ng/ml; p:0.129) or between SCLC and NSCLC patients (0.53+0.18 ng/ml vs 0.52+0.20 ng/ml; p:0.458). No significant correlation was found between serum nesfatin-1 values and BMI. In conclusion, loss of fat mass may decrease serum nesfatin-1 level in lung cancer patients with weight loss. The future studies which explore biological significance of low serum nesfatin-1 level in cancer are needed. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：1 / 3

页数：3

共 14 条

[1] High plasma nesfatin-1 level in patients with major depressive disorder [J].