Conversion of epidermal growth factor receptor 2 and hormone receptor expression in breast cancer metastases to the brain

被引：85

作者：

Duchnowska, Renata ^{[1
]}

Dziadziuszko, Rafal ^{[2
]}

Trojanowski, Tomasz ^{[3
,4
]}

Mandat, Tomasz ^{[5
,6
]}

Och, Waldemar ^{[7
]}

Czartoryska-Arlukowicz, Bogumila ^{[8
]}

Radecka, Barbara ^{[9
]}

Olszewski, Wojciech ^{[6
,10
]}

Szubstarski, Franciszek ^{[11
]}

Kozlowski, Wojciech ^{[12
]}

Jarosz, Bozena ^{[3
,4
]}

Rogowski, Wojciech ^{[13
]}

Kowalczyk, Anna ^{[2
]}

Limon, Janusz ^{[14
]}

Biernat, Wojciech ^{[15
]}

Jassem, Jacek ^{[2
]}

机构：

[1] Mil Inst Med, Dept Oncol, PL-00909 Warsaw, Poland

[2] Med Univ Gdansk, Dept Oncol & Radiotherapy, PL-80211 Gdansk, Poland

[3] Med Univ Lublin, Dept Neurosurg, PL-20954 Lublin, Poland

[4] Med Univ Lublin, Childrens Neurosurg Clin, PL-20954 Lublin, Poland

[5] Maria Sklodowska Curie Mem Canc Ctr, Dept Neurosurg, PL-02781 Warsaw, Poland

[6] Inst Oncol, PL-02781 Warsaw, Poland

[7] Voivodal Specialist Hosp, Dept Neurosurg, PL-10561 Olsztyn, Poland

[8] Bialystok Oncol Ctr, Dept Clin Oncol, PL-15027 Bialystok, Poland

[9] Opole Oncol Ctr, Dept Clin Oncol, PL-45060 Opole, Poland

[10] Maria Sklodowska Curie Mem Canc Ctr, Dept Pathol, PL-02781 Warsaw, Poland

[11] Lublin Oncol Ctr, Dept Pathol, PL-20090 Lublin, Poland

[12] Mil Inst Med, Dept Pathomorphol, PL-00909 Warsaw, Poland

[13] Warmia & Masuria Oncol Ctr, Dept Chemotherapy, PL-10228 Olsztyn, Poland

[14] Med Univ Gdansk, Dept Biol & Genet, PL-80211 Gdansk, Poland

[15] Med Univ Gdansk, Dept Pathomorphol, PL-80214 Gdansk, Poland

来源：

BREAST CANCER RESEARCH | 2012年 / 14卷 / 04期

关键词：

CENTRAL-NERVOUS-SYSTEM; TISSUE CONFIRMATION; CNS METASTASES; ESTROGEN; IMPACT; CARCINOMA; DISEASE; TUMORS; HETEROGENEITY; DISCORDANCE;

D O I：

10.1186/bcr3244

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: We investigated the status of estrogen receptor alpha (ER alpha), progesterone receptor (PR), and epidermal growth factor receptor 2 (HER2) in primary tumor and in the corresponding brain metastases in a consecutive series of breast cancer patients. Additionally, we studied factors potentially influencing conversion and evaluated its association with survival. Methods: The study group included 120 breast cancer patients. ER alpha, PR, and HER2 status in primary tumors and in matched brain metastases was determined centrally by immunohistochemistry and/or fluorescence in situ hybridization. Results: Using the Allred score of >= 3 as a threshold, conversion of ER alpha and PR in brain metastases occurred in 29% of cases for both receptors, mostly from positive to negative. Conversion of HER2 occurred in 14% of patients and was more balanced either way. Time to brain relapse and the use of chemotherapy or trastuzumab did not influence conversion, whereas endocrine therapy induced conversion of ER alpha (P = 0.021) and PR (P = 0.001), mainly towards their loss. Receptor conversion had no significant impact on survival. Conclusions: Receptor conversion, particularly loss of hormone receptors, is a common event in brain metastases from breast cancer, and endocrine therapy may increase its incidence. Receptor conversion does not significantly affect survival.

引用

页数：11

共 44 条

[1]

Allred DC, 1998, MODERN PATHOL, V11, P155

[2] Tissue confirmation of disease recurrence in breast cancer patients: Pooled analysis of multi-centre, multi-disciplinary prospective studies [J].