p63 in epithelial development

被引：118

作者：

Candi, E. ^{[1
]}

Cipollone, R. ^{[1
]}

Cervoa, P. Rivetti di Val ^{[1
]}

Gonfloni, S. ^{[2
]}

Melino, G. ^{[1
,3
]}

Knight, R. ^{[3
]}

机构：

[1] IRCCS, Biochem Lab IDI, I-00133 Rome, Italy

[2] Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

[3] Univ Leicester, Toxicol Unit, MRC, Leicester LE1 9HN, Leics, England

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 20期

基金：

英国医学研究理事会;

关键词：

p63; epidermis; cornification; skin; development; Itch; ubiquitin E3 ligase;

D O I：

10.1007/s00018-008-8119-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The epidermis, the outer layer of the skin composed of keratinocytes, is a stratified epithelium that functions as a barrier to protect the organism from dehydration and external insults. The epidermis develops following the action of the transcription factor p63, a member of the p53 family of transcription factors. The Trp63 gene contains two promoters driving the production of distinct proteins, one with an N-terminal transactivation domain (TAp63) and one without (Delta Np63), although their relative contribution to epidermal development is not clearly established. Trp63 mutations are involved in the pathogenesis of several human diseases, phenotypically characterized by ectodermal dysplasia. In this review, we summarize the current advances that have been made in understanding the role of p63 in epidermal morphogenesis.

引用

页码：3126 / 3133

页数：8

共 56 条

[51]

Wu GJ, 2005, CANCER RES, V65, P758

[52] P63 and p73: P53 mimics, menaces and more [J].