p63 in epithelial development

被引：118

作者：

Candi, E. ^{[1
]}

Cipollone, R. ^{[1
]}

Cervoa, P. Rivetti di Val ^{[1
]}

Gonfloni, S. ^{[2
]}

Melino, G. ^{[1
,3
]}

Knight, R. ^{[3
]}

机构：

[1] IRCCS, Biochem Lab IDI, I-00133 Rome, Italy

[2] Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

[3] Univ Leicester, Toxicol Unit, MRC, Leicester LE1 9HN, Leics, England

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 20期

基金：

英国医学研究理事会;

关键词：

p63; epidermis; cornification; skin; development; Itch; ubiquitin E3 ligase;

D O I：

10.1007/s00018-008-8119-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The epidermis, the outer layer of the skin composed of keratinocytes, is a stratified epithelium that functions as a barrier to protect the organism from dehydration and external insults. The epidermis develops following the action of the transcription factor p63, a member of the p53 family of transcription factors. The Trp63 gene contains two promoters driving the production of distinct proteins, one with an N-terminal transactivation domain (TAp63) and one without (Delta Np63), although their relative contribution to epidermal development is not clearly established. Trp63 mutations are involved in the pathogenesis of several human diseases, phenotypically characterized by ectodermal dysplasia. In this review, we summarize the current advances that have been made in understanding the role of p63 in epidermal morphogenesis.

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收藏

页码：3126 / 3133

页数：8

相关论文

共 56 条

[1] Key role of p63 in BMP-4-induced epidermal commitment of embryonic stem cells [J].

Aberdam, Daniel ;

Gambaro, Karen ;

Rostagno, Philippe ;

Aberdam, Edith ;

Divonne, Stephanie de la Forest ;

Rouleau, Matthieu .

CELL CYCLE, 2007, 6 (03) :291-294

[2] LORICRIN EXPRESSION IS COORDINATED WITH OTHER EPIDERMAL PROTEINS AND THE APPEARANCE OF LIPID LAMELLAR GRANNIES IN DEVELOPMENT [J].

BICKENBACH, JR ;

GREER, JM ;

BUNDMAN, DS ;

ROTHNAGEL, JA ;

ROOP, DR .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 104 (03) :405-410

[3]

BICKENBACH JR, 1994, DEVELOPMENT, V120, P2369

[4] Epidermal stem cells of the skin [J].

Blanpain, Cedric ;

Fuchs, Elaine .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2006, 22 :339-373

[5] Canonical Notch signaling functions as a commitment switch in the epidermal lineage [J].

Blanpain, Cedric ;

Lowry, William E. ;

Pasolli, H. Amalia ;

Fuchs, Elaine .

GENES & DEVELOPMENT, 2006, 20 (21) :3022-3035

[6] Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice [J].

Candi, E. ;

Rufini, A. ;

Terrinoni, A. ;

Dinsdale, D. ;

Ranalli, M. ;

Paradisi, A. ;

De Laurenzi, V. ;

Spagnoli, L. G. ;

Catani, M. V. ;

Ramadan, S. ;

Knight, R. A. ;

Melino, G. .

CELL DEATH AND DIFFERENTIATION, 2006, 13 (06) :1037-1047

[7] The cornified envelope: A model of cell death in the skin [J].

Candi, E ;

Schmidt, R ;

Melino, G .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (04) :328-340

[8] ΔNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2 [J].

Candi, Eleonora ;

Rufini, Alessandro ;

Terrinoni, Alessandro ;

Giamboi-Miraglia, Alessandro ;

Lena, Anna Maria ;

Mantovani, Roberto ;

Knight, Richard ;

Melino, Gerry .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (29) :11999-12004

[9] p63 is upstream of IKKα in epidermal development [J].

Candi, Eleonora ;

Terrinoni, Alessandro ;

Rufini, Alessandro ;

Chikh, Anissa ;

Lena, Anna Maria ;

Suzuki, Yasuhiro ;

Sayan, Berna S. ;

Knight, Richard A. ;

Melino, Gerry .

JOURNAL OF CELL SCIENCE, 2006, 119 (22) :4617-4622

[10] p63 regulates an adhesion programme and cell survival in epithelial cells [J].

Carroll, Danielle K. ;

Carroll, Jason S. ;

Leong, Chee-Onn ;

Cheng, Fang ;

Brown, Myles ;

Mills, Alea. A. ;

Brugge, Joan S. ;

Ellisen, Leif W. .

NATURE CELL BIOLOGY, 2006, 8 (06) :551-561

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