Peroxisome proliferator-activated receptor delta and cardiovascular disease

被引：30

作者：

Ehrenborg, Ewa ^{[1
]}

Skogsberg, Josefin ^{[2
]}

机构：

[1] Karolinska Inst, Atherosclerosis Res Unit, Karolinska Univ Hosp, Dept Med,Ctr Mol Med, SE-17176 Stockholm, Sweden

[2] Karolinska Inst, Cardiovasc Genom Grp, Vasc Biol Unit, Dept Med Biochem & Biophys, SE-17177 Stockholm, Sweden

来源：

ATHEROSCLEROSIS | 2013年 / 231卷 / 01期

基金：

瑞典研究理事会;

关键词：

Peroxisome proliferator-activated receptor delta; Cardiovascular disease; Risk factors; Mouse models; Agonist; Single nucleotide polymorphism; LOW-DENSITY LIPOPROTEIN; SMOOTH-MUSCLE-CELLS; CORONARY-ARTERY-DISEASE; NF-KAPPA-B; PPAR-DELTA; INSULIN-RESISTANCE; ENDOTHELIAL-CELLS; METABOLIC SYNDROME; SKELETAL-MUSCLE; INFLAMMATORY RESPONSE;

D O I：

10.1016/j.atherosclerosis.2013.08.027

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent reports have shown that peroxisome proliferator-activated receptor delta (PPARD) plays an important role in different vascular processes suggesting that PPARD is a significant modulator of cardiovascular disease. This review will focus on PPARD in relation to cardiovascular risk factors based on cell, animal and human data. Mouse studies suggest that PPARD is an important metabolic modulator that may have implications for cardiovascular disease (CVD). Specific human PPARD gene variants show no clear association with CVD but interactions between variants and lifestyle factors might influence disease risk. During recent years, development of specific and potent PPARD agonists has also made it possible to study the effects of PPARD activation in humans. PPARD agonists seem to exert beneficial effects on dyslipidemia and insulin-resistant syndromes but safety issues have been raised due to the role that PPARD plays in cell proliferation. Thus, large long term outcome as well as detailed safety and tolerability studies are needed to evaluate whether PPARD agonists could be used to treat CVD in humans. (c) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：95 / 106

页数：12

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