Coniochaetones E-I, new 4H-chromen-4-one derivatives from the Cordyceps-colonizing fungus Fimetariella sp.

被引：19

作者：

Deng, Lianwu ^{[1
,3
]}

Niu, Shubing ^{[1
,3
]}

Liu, Xingzhong ^{[1
]}

Che, Yongsheng ^{[1
,2
]}

Li, Erwei ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100190, Peoples R China

[2] Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

FITOTERAPIA | 2013年 / 89卷

基金：

中国国家自然科学基金;

关键词：

Coniochaetone; Cordyceps-colonizing fungus; Structure elucidation; Antifungal activity; Cytotoxic activity;

D O I：

10.1016/j.fitote.2013.04.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new 4H-chromen-4-one derivatives coniochaetones E-I (1-5), along with the known compounds coniochaetones B (6) and A (7) have been isolated from solid cultures of the Cordyceps-colonizing fungus Fimetariella sp. Their structures were elucidated primarily by NMR spectroscopy and the absolute configurations of compounds 1-3 were assigned using the modified Mosher's method. Compound 4 showed weak cytotoxic activity against HeLa cells with IC50 values of 72.8 mu M. The co-isolated known compound 6 showed modest inhibitory effects against Aspergilus fumigates, Fusarium oxysporum and Fusarium nivale. (c) 2013 Elsevier B.V. All rights reserved.

引用

页码：8 / 14

页数：7

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