An ammonia equivalent for the palladium-catalyzed amination of aryl halides and triflates

被引：352

作者：

Wolfe, JP ^{[1
]}

Ahman, J ^{[1
]}

Sadighi, JP ^{[1
]}

Singer, RA ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 36期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(97)01465-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Commercially available benzophenone imine serves as a convenient ammonia equivalent in the palladium-catalyzed amination of aryl halides and triflates. The benzophenone imine adducts can be cleaved directly to the corresponding primary anilines by catalytic hydrogenation or treatment with hydroxylamine hydrochloride or a catalytic amount of HCl in wet THF. (C) 1997 Elsevier Science Ltd.

引用

页码：6367 / 6370

页数：4

共 12 条

[1] A second-generation catalyst for aryl halide amination: Mixed secondary amines from aryl halides and primary amines catalyzed by (DPPF)PdCl2 [J].