Salmonella typhimurium outer membrane remodeling:: role in resistance to host innate immunity

被引：182
|
作者：
Ernst, RK
Guina, T
Miller, SI
机构：
[1] Univ Washington, Dept Med, Seattle, WA 98195 USA
[2] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA
来源：
MICROBES AND INFECTION | 2001年 / 3卷 / 14-15期
关键词：
Salmonella; pho-phoQ; LPS; membrane remodeling; antimicrobial peptides; innate immune system; resistance;
D O I：
10.1016/S1286-4579(01)01494-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Resistance to innate immunity is essential for salmonellae pathogenesis. The salmonellae PhoP/PhoQ regulators sense host environments to promote remodeling of the bacterial envelope. This remodeling includes enzymes that modify lipopolysaccharide (LPS). Modified LPS promotes bacterial survival by increasing resistance to cationic antimicrobial peptides and by altered host recognition of LPS. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
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页码：1327 / 1334
页数：8
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