Salmonella typhimurium outer membrane remodeling:: role in resistance to host innate immunity

被引：182
作者：
Ernst, RK
Guina, T
Miller, SI
机构：
[1] Univ Washington, Dept Med, Seattle, WA 98195 USA
[2] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA
来源：
MICROBES AND INFECTION | 2001年 / 3卷 / 14-15期
关键词：
Salmonella; pho-phoQ; LPS; membrane remodeling; antimicrobial peptides; innate immune system; resistance;
D O I：
10.1016/S1286-4579(01)01494-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Resistance to innate immunity is essential for salmonellae pathogenesis. The salmonellae PhoP/PhoQ regulators sense host environments to promote remodeling of the bacterial envelope. This remodeling includes enzymes that modify lipopolysaccharide (LPS). Modified LPS promotes bacterial survival by increasing resistance to cationic antimicrobial peptides and by altered host recognition of LPS. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码：1327 / 1334
页数：8
相关论文
共 52 条
  • [1] SALMONELLA-TYPHIMURIUM ACTIVATES VIRULENCE GENE-TRANSCRIPTION WITHIN ACIDIFIED MACROPHAGE PHAGOSOMES
    ARANDA, CMA
    SWANSON, JA
    LOOMIS, WP
    MILLER, SI
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) : 10079 - 10083
  • [2] TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
    Arbour, NC
    Lorenz, E
    Schutte, BC
    Zabner, J
    Kline, JN
    Jones, M
    Frees, K
    Watt, JL
    Schwartz, DA
    [J]. NATURE GENETICS, 2000, 25 (02) : 187 - +
  • [3] A deacylase in Rhizobium leguminosarum membranes that cleaves the 3-O-linked β-hydroxymyristoyl moiety of lipid A precursors
    Basu, SS
    White, KA
    Que, NLS
    Raetz, CRH
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (16) : 11150 - 11158
  • [4] Tlr4: central component of the sole mammalian LPS sensor
    Beutler, B
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2000, 12 (01) : 20 - 26
  • [5] Transfer of palmitate from phospholipids to lipid A in outer membranes of Gram-negative bacteria
    Bishop, RE
    Gibbons, HS
    Guina, T
    Trent, MS
    Miller, SI
    Raetz, CRH
    [J]. EMBO JOURNAL, 2000, 19 (19) : 5071 - 5080
  • [6] The Salmonella selC locus contains a pathogenicity island mediating intramacrophage survival
    BlancPotard, AB
    Groisman, EA
    [J]. EMBO JOURNAL, 1997, 16 (17) : 5376 - 5385
  • [7] The Nramp1 protein and its role in resistance to infection and macrophage function
    Canonne-Hergaux, F
    Gruenheid, S
    Govoni, G
    Gros, P
    [J]. PROCEEDINGS OF THE ASSOCIATION OF AMERICAN PHYSICIANS, 1999, 111 (04) : 283 - 289
  • [8] Identification of a domain in Rck, a product of the Salmonella typhimurium virulence plasmid, required for both serum resistance and cell invasion
    Cirillo, DM
    Heffernan, EJ
    Wu, L
    Harwood, J
    Fierer, J
    Guiney, DG
    [J]. INFECTION AND IMMUNITY, 1996, 64 (06) : 2019 - 2023
  • [9] Lipid A diversity and the innate host response to bacterial infection
    Darveau, RP
    [J]. CURRENT OPINION IN MICROBIOLOGY, 1998, 1 (01) : 36 - 42
  • [10] Immunosuppression and nitric oxide production induced by parenteral live Salmonella vaccines do not correlate with protective capacity: a phoP::Tn10 mutant does not suppress but does protect
    Eisenstein, TK
    Meissler, JJ
    Miller, SI
    Stocker, BAD
    [J]. VACCINE, 1998, 16 (01) : 24 - 32
123456