Sustained Cognitive Impairments After Clinical Recovery of Severe Depression

被引：35

作者：

Boeker, Heinz ^{[1
]}

Schulze, Jan ^{[1
]}

Richter, Andre ^{[1
]}

Nikisch, Georg ^{[2
]}

Schuepbach, Daniel ^{[1
]}

Grimm, Simone ^{[1
,3
,4
]}

机构：

[1] Psychiat Univ Hosp, Clin Affect Disorders & Gen Psychiat, Zurich, Switzerland

[2] Psychiat Hosp Fulda, Fulda, Germany

[3] Charite, Dept Psychiat, Berlin, Germany

[4] Free Univ Berlin, Berlin, Germany

来源：

JOURNAL OF NERVOUS AND MENTAL DISEASE | 2012年 / 200卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

Unipolar depression; neuropsychological deficits; trait marker; MAJOR DEPRESSION; NEUROPSYCHOLOGICAL IMPAIRMENTS; NEUROCOGNITIVE FUNCTION; EXECUTIVE FUNCTIONS; EUTHYMIC PHASE; MEMORY; ATTENTION; YOUNGER;

D O I：

10.1097/NMD.0b013e318266ba14

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuropsychological impairment is prominent in patients with depression, but it is unclear whether deficits persist after clinical response. This study aimed to investigate neuropsychological functions in the course of the illness. Depressive patients were investigated in the acute state and after clinical response using an extensive neuropsychological test battery. After clinical response, there was only a partial improvement in learning and memory and there were no changes regarding working memory, executive functions, and attention. Transient impairments in visual learning and memory suggest a depression-related state effect. The continuing deficits in attention, working memory, and executive function might be considered a trait marker.

引用

页码：773 / 776

页数：4

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