Microbial epoxide hydrolases for preparative biotransformations

被引：167
作者：
Steinreiber, A [1 ]
Faber, K [1 ]
机构：
[1] Graz Univ, Dept Chem Organ & Bioorgan Chem, A-8010 Graz, Austria
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2001年 / 12卷 / 06期
基金：
奥地利科学基金会;
关键词：
D O I：
10.1016/S0958-1669(01)00262-2
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Epoxide hydrolases from microbial sources are highly versatile biocatalysts for the asymmetric hydrolysis of epoxides on a preparative scale. Besides kinetic resolution, which furnishes the corresponding vicinal diol and remaining non-hydrolysed epoxide in nonracemic form, enantioconvergent processes are possible: these are highly attractive as they lead to the formation of a single enantiomeric diol from a racemic oxirane. The data accumulated over recent years reveal a common picture of the substrate structure selectivity pattern of microbial epoxide hydrolases and indicate that substrates of various structural types can be selectively hydrolysed with enzymes from certain microbial sources.
引用
收藏
页码：552 / 558
页数：7
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