Inhaled nitric oxide decreases the bacterial load in a rat model of Pseudomonas aeruginosa pneumonia

被引：36

作者：

Miller, Christopher C. ^{[1
,2
]}

Hergott, Christopher A. ^{[3
,4
]}

Rohan, Marta ^{[3
,4
]}

Arsenault-Mehta, Kyle ^{[3
,4
]}

Doering, Gerd ^{[5
]}

Mehta, Sanjay ^{[3
,4
]}

机构：

[1] Univ British Columbia, Div Resp Med, Vancouver, BC V5Z 1M9, Canada

[2] Univ British Columbia, Div Infect Dis, Vancouver, BC V5Z 1M9, Canada

[3] Lawson Hlth Res Inst, Ctr Crit Illness Res, London Hlth Sci Ctr, Dept Med,Resp Div, London, ON, Canada

[4] Western Univ, Schulich Sch Med & Dent, Dept Med, London, ON, Canada

[5] Univ Klinikum Tubingen, Inst Med Microbiol & Hyg, Tubingen, Germany

来源：

JOURNAL OF CYSTIC FIBROSIS | 2013年 / 12卷 / 06期

关键词：

Cystic fibrosis; Nitric oxide; Inhalation; P. aeruginosa pneumonia; Myeloperoxidase; CYSTIC-FIBROSIS; ANTIMICROBIAL ACTIVITY; INFECTION; INJURY; ADULTS;

D O I：

10.1016/j.jcf.2013.01.008

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Gaseous nitric oxide (NO) is bactericidal in vitro. However whether and how it can be used for the treatment of bacterial lung infections in patients with cystic fibrosis is unclear. Here we assessed the bactericidal effect of intermittently inhaled 160 ppm NO for 30 min every 4 h in a Pseudomonas aeruginosa pneumonia model in rats. NO significantly reduced P. aeruginosa colony count in rat lungs but did not affect neutrophil myeloperoxidase function methemoglobin percentage nor plasma nitrite/nitrate levels. This regimen warrants exploration in infected patients with cystic fibrosis. (C) 2013 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

引用

页码：817 / 820

页数：4

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