Palladium catalysed Heck and enantioselective allylic substitution reactions using reverse phase silica supports

被引：46

作者：

Anson, MS

Mirza, AR

Tonks, L

Williams, JMJ ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(99)01485-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of reverse phase controlled-pore glass beads in Heck reactions affords the products with low levels of palladium leaching. Additionally, an enantioselective palladium catalysed allylic substitution reaction has been achieved with high enantiomeric excess and a low level of leaching (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：7147 / 7150

页数：4

相关论文

共 13 条

[1] Transition metal catalysed reactions using glass bead technology [J].

Anson, MS ;

Leese, MP ;

Tonks, L ;

Williams, JMJ .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1998, (21) :3529-3538

[2]

DAVIS ME, 1992, CHEMTECH, P498

[3] ASYMMETRIC PALLADIUM-CATALYZED ALLYLIC SUBSTITUTION USING PHOSPHORUS-CONTAINING OXAZOLINE LIGANDS [J].

DAWSON, GJ ;

FROST, CG ;

WILLIAMS, JMJ .

TETRAHEDRON LETTERS, 1993, 34 (19) :3149-3150

[4]

DEAN PDG, 1985, MIDDLE AFFINITY CHRO, P25

[5] SYNTHESIS AND INVESTIGATION OF PHOSPHINE-LIGANDS CONTAINING CATIONIC GUANIDINO FUNCTIONS IN AQUEOUS HECK REACTIONS [J].

DIBOWSKI, H ;

SCHMIDTCHEN, FP .

TETRAHEDRON, 1995, 51 (08) :2325-2330

[6] SELECTIVITY IN PALLADIUM CATALYZED ALLYLIC SUBSTITUTION [J].

FROST, CG ;

HOWARTH, J ;

WILLIAMS, JMJ .

TETRAHEDRON-ASYMMETRY, 1992, 3 (09) :1089-1122

[7] PALLADIUM-CATALYZED, ARYLATION OF ETHYLENE (THE HECK REACTION) UNDER AQUEOUS CONDITIONS [J].

KIJI, JS ;

OKANO, T ;

HASEGAWA, T .

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 1995, 97 (02) :73-77

[8] Optimisation of palladium-based supported liquid-phase catalysts in the Heck reaction [J].

Mirza, AR ;

Anson, MS ;

Hellgardt, K ;

Leese, MP ;

Thompson, DF ;

Tonks, L ;

Williams, JMJ .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 1998, 2 (05) :325-331

[9]

Schneider P, 1996, NEW J CHEM, V20, P545

[10] PHOSPHINOARYLOXAZOLINES AND PHOSPHINOALKYLOXAZOLINES AS NEW CHIRAL LIGANDS FOR ENANTIOSELECTIVE CATALYSIS - VERY HIGH ENANTIOSELECTIVITY IN PALLADIUM CATALYZED ALLYLIC SUBSTITUTIONS [J].

SPRINZ, J ;

HELMCHEN, G .

TETRAHEDRON LETTERS, 1993, 34 (11) :1769-1772