Multi-microarray identifies lower AQP9 expression in adjuvant chemotherapy nonresponders with stage III colorectal cancer

被引：20

作者：

Dou, Ruoxu ^{[1
]}

Deng, Yanhong ^{[2
]}

Huang, Lanlan ^{[3
]}

Fu, Shijun ^{[4
]}

Tan, Shuyun ^{[1
]}

Wang, Lei ^{[1
]}

Lian, Lei ^{[1
]}

Fang, Lekun ^{[1
]}

Fan, Xinjuan ^{[5
]}

Jin, Gang ^{[4
]}

Liu, Huanliang ^{[3
]}

Wang, Jianping ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Dept Colorectal Surg, Affiliated Hosp 6, Guangzhou 510655, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Dept Clin Oncol, Affiliated Hosp 6, Guangzhou 510655, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Gastrointestinal Inst, Affiliated Hosp 6, Guangzhou 510655, Guangdong, Peoples R China

[4] Shanghai Biochip Co Ltd, Shanghai, Peoples R China

[5] Sun Yat Sen Univ, Dept Pathol, Affiliated Hosp 6, Guangzhou 510655, Guangdong, Peoples R China

来源：

CANCER LETTERS | 2013年 / 336卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Microarray; AQP9; Chemosensitivity; COLON-CANCER; THYMIDYLATE SYNTHASE; GENE-EXPRESSION; PREDICTIVE-VALUE; DUKES-B; FLUOROURACIL; LEUCOVORIN; BREAST; SENSITIVITY; AQUAPORIN-9;

D O I：

10.1016/j.canlet.2013.04.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Approximately 25% of stage III colorectal cancer patients do not benefit from standard adjuvant chemotherapies. To identify biomarkers for nonresponders, fresh-frozen tissues of 19 nonresponders and 16 responders were analyzed with gene expression and microRNA arrays. Fifty-nine genes and 17 miRNAs were differentially expressed by at least two folds. AQP9, SATB2, and WIF1 were simultaneously lower expressed in the nonresponders and modulated by the differentially expressed miRNAs. RT-PCR validated the differential expression of AQP9 (p = 0.035). In conclusion, lower AQP9 gene expression is related with non-response to adjuvant chemotherapy, showing potential as predictive marker and therapeutic target. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：106 / 113

页数：8

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