Influence of different rehabilitative aerobic exercise programs on (anti-) inflammatory immune signalling, cognitive and functional capacity in persons with MS - study protocol of a randomized controlled trial

被引：21

作者：

Joisten, Niklas ^{[1
]}

Rademacher, Annette ^{[1
,2
]}

Bloch, Wilhelm ^{[1
]}

Schenk, Alexander ^{[1
]}

Oberste, Max ^{[1
]}

Dalgas, Ulrik ^{[3
]}

Langdon, Dawn ^{[4
]}

Caminada, Daniel ^{[5
]}

Purde, Mette-Triin ^{[5
]}

Gonzenbach, Roman ^{[2
]}

Kool, Jan ^{[2
]}

Zimmer, Philipp ^{[1
,6
]}

Bansi, Jens ^{[2
]}

机构：

[1] German Sport Univ Cologne, Dept Mol & Cellular Sport Med, Inst Cardiovasc Res & Sports Med, Sportpk Mungersdorf 6, D-50933 Cologne, Germany

[2] Kliniken Valens, Dept Neurol, Rehabil Klin Valens, Taminapl 1, CH-7317 Valens, Switzerland

[3] Aarhus Univ, Dept Publ Hlth, Sect Sport Sci, Dalgas Ave 4, DK-8000 Aarhus C, Denmark

[4] Royal Holloway Univ London, Egham TW20 0EX, Surrey, England

[5] Lab Med Zentrum Dr Risch, Lagerstr 30, CH-9470 Buchs, Switzerland

[6] German Canc Res Ctr, Div Phys Act Prevent & Canc, Neuenheimer Feld 581, D-69120 Heidelberg, Germany

来源：

BMC NEUROLOGY | 2019年 / 19卷 / 1期

关键词：

Multiple sclerosis; Rehabilitation; Exercise; High-intensity interval exercise; Immune signalling; Inflammation; Kynurenine pathway; Cognition; MULTIPLE-SCLEROSIS; KYNURENINE PATHWAY; THERAPEUTIC TARGET; SYSTEM; SCALE; IMPAIRMENT; METABOLISM; EXPRESSION; CYTOKINE; FATIGUE;

D O I：

10.1186/s12883-019-1267-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BackgroundStudies have shown positive effects of therapeutic exercise on motor- and cognitive function as well as on psychosocial outcomes in persons with multiple sclerosis (MS). A reduction of inflammatory stress through physical exercise has been suspected as one key mechanism, mediating the positive effects of exercise in the context of MS. The primary objective of this trial is to investigate the acute and chronic effects of different exercise modalities on (anti-)inflammatory immune signalling as well as on cognitive and functional capacity in persons with MS.MethodsA two armed single-blind randomized controlled design will investigate 72 persons with relapsing remitting or secondary progressive MS (EDSS 3.0-6.0), during 3weeks of inpatient rehabilitation. Participants will be randomized into either a high-intensity interval training (HIIT) or a moderate continuous training group; the latter represents the local standard therapy (ST). Both groups will exercise 3x per week. The HIIT group will perform 5x1.5-min high-intensive exercise bouts at 95-100% of their maximum heart rate (HRmax) followed by active breaks of unloaded pedalling (60% HRmax) for 2min. In contrast, the ST group will exercise for 24min continuously at 65% of HRmax. The proportion of circulating regulatory T-cells will be measured as primary outcome. Secondary outcomes comprise numbers and proportions of further immune cells including Th17-cells, soluble factors ((anti-) inflammatory cytokines, tryptophan metabolites), endurance capacity, cognitive performance, processing skills for activities of daily living, fatigue, depression and healthcare-related quality of life. Outcomes will be assessed before (T-0) and after (T-3) the 3-week exercise intervention program. Blood samples of T-0 will be taken immediately before the first exercise session. Additionally, blood samples for the soluble factors will be collected immediately after (T-1) and three hours (T-2) after the first exercise session of each group.DiscussionThis study will be the first to investigate both acute and chronic effects of aerobic exercise on immune function and disease associated biomarkers in persons with MS. Combining biological analyses with cognitive and functional capacity assessments may contribute to a better understanding of responses to rehabilitative training, needed to improve exercise recommendations for persons with MS.

引用

页数：9

共 48 条

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