Embryonic stem cell-derived glial precursors:: A source of myelinating transplants

被引：715
作者：
Brüstle, O
Jones, KN
Learish, RD
Karram, K
Choudhary, K
Wiestler, OD
Duncan, ID
McKay, RDG
机构：
[1] Univ Bonn, Med Ctr, Dept Neuropathol, D-53105 Bonn, Germany
[2] NINDS, Mol Biol Lab, NIH, Bethesda, MD 20892 USA
[3] Univ Wisconsin, Sch Vet Med, Dept Med Sci, Madison, WI 53706 USA
来源：
SCIENCE | 1999年 / 285卷 / 5428期
关键词：
D O I：
10.1126/science.285.5428.754
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Self-renewing, totipotent embryonic stem (ES) cells may provide a virtually unlimited donor source for transplantation. A protocol that permits the in vitro generation of precursors for oligodendrocytes and astrocytes from ES cells was devised. Transplantation in a rat model of a human myelin disease shows that these ES cell-derived precursors interact with host neurons and efficiently myelinate axons in brain and spinal cord. Thus, ES cells can serve as a valuable source of cell type-specific somatic precursors for neural transplantation.
引用
收藏
页码：754 / 756
页数：3
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