X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells

被引：23
作者：
Chien, Chia-Chi [1 ,2 ]
Chen, Hsiang-Hsin [1 ]
Lai, Sheng-Feng [1 ]
Hwu, Y. [1 ,2 ,3 ]
Petibois, Cyril [4 ]
Yang, C. S. [5 ]
Chu, Y. [6 ]
Margaritondo, G. [7 ]
机构：
[1] Acad Sinica, Inst Phys, Taipei 115, Taiwan
[2] Natl Tsing Hua Univ, Dept Engn & Syst Sci, Hsinchu 300, Taiwan
[3] Natl Cheng Kung Univ, Adv Optoelect Technol Ctr, Tainan 701, Taiwan
[4] Univ Bordeaux, CNRS UMR CBMN 5248, F-33405 Talence, France
[5] Natl Hlth Res Inst, Ctr Nanomed Res, Miaoli 350, Taiwan
[6] Brookhaven Natl Lab, Natl Synchrotron Light Source 2, Upton, NY 11973 USA
[7] Ecole Polytech Fed Lausanne, CH-1015 Lausanne, Switzerland
来源：
SCIENTIFIC REPORTS | 2012年 / 2卷
关键词：
CELLULAR UPTAKE; QUANTUM DOTS; CONTRAST; CANCER; RADIOLOGY; MODELS;
D O I：
10.1038/srep00610
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We show that sufficient concentrations of gold nanoparticles produced by an original synthesis method in EMT-6 and CT-26 cancer cells make it possible to detect the presence, necrosis and proliferation of such cells after inoculation in live mice. We first demonstrated that the nanoparticles do not interfere with the proliferation process. Then, we observed significant differences in the tumor evolution and the angiogenesis process after shallow and deep inoculation. A direct comparison with pathology optical images illustrates the effectiveness of this approach.
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页数：6
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