Energy and caloric restriction, and fasting and cancer: a narrative review

被引：29

作者：

Ibrahim, Ezzeldin M. ^{[1
]}

Al-Foheidi, Meteb H. ^{[2
,3
]}

Al-Mansour, Mubarak M. ^{[2
,3
,4
]}

机构：

[1] Int Med Ctr, Oncol Ctr, Jeddah, Saudi Arabia

[2] King Abdul Aziz Med City, Princess Noorah Oncol Ctr, Minist Natl Guard Hlth Affairs Western Reg MNGHA, Jeddah, Saudi Arabia

[3] King Saud Bin Abdulaziz Univ Hlth Sci, Coll Med, Jeddah, Saudi Arabia

[4] King Abdul Aziz Med City, Minist Natl Guard Hlth Affairs Western Reg, Princess Noorah Oncol Ctr, Adult Med Oncol, POB 9515, Jeddah 21423, Saudi Arabia

来源：

SUPPORTIVE CARE IN CANCER | 2021年 / 29卷 / 05期

关键词：

Energy restriction; Caloric restriction; Fasting; Cancer; IGF BINDING PROTEIN-3; TUMOR-GROWTH; MOLECULAR-MECHANISMS; KETOGENIC DIET; OVARIAN-CANCER; CELL-DEATH; AUTOPHAGY; BREAST; RADIATION; CARBOHYDRATE;

D O I：

10.1007/s00520-020-05879-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dietary interventions have a significant impact on body metabolism. The sensitivity of cancer cells to nutrient and energy deficiency is an evolving characteristic of cancer biology. Preclinical studies provided robust evidence that energy and caloric restrictions could hinder both cancer growth and progression, besides enhancing the efficacy of chemotherapy and radiation therapy. Moreover, several, albeit low-powered, clinical trials have demonstrated clinical benefits in cancer patients. Future research will inform and firmly establish the potential efficacy and safety of these dietary interventions. Here, we review the current evidence and ongoing research investigating the relationship between various dietary restriction approaches and cancer outcomes.

引用

页码：2299 / 2304

页数：6

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