Absorption and tolerability of aqueous chlorhexidine gluconate used for skin antisepsis prior to catheter insertion in preterm neonates

被引：53

作者：

Chapman, A. K. ^{[1
]}

Aucott, S. W. ^{[1
]}

Gilmore, M. M. ^{[1
]}

Advani, S. ^{[2
]}

Clarke, W. ^{[3
]}

Milstone, A. M. ^{[2
,4
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Div Neonatol, Dept Pediat, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Div Pediat Infect Dis, Dept Pediat, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21287 USA

[4] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21287 USA

来源：

JOURNAL OF PERINATOLOGY | 2013年 / 33卷 / 10期

基金：

美国国家卫生研究院;

关键词：

chlorhexidine gluconate; prematurity; neonates; drug safety; drug toxicity; BIRTH-WEIGHT INFANTS; PERCUTANEOUS-ABSORPTION; PREMATURE-INFANT; CHEMICAL BURNS; CORD CARE; PREVENTION; IMPACT; INFECTION; NEWBORN; SAFETY;

D O I：

10.1038/jp.2013.61

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: To assess chlorhexidine absorption and skin tolerability in premature infants, following skin antisepsis with 2% aqueous chlorhexidine gluconate (CHG) prior to peripherally inserted central catheter (PICC) placement. STUDY DESIGN: Neonates less than 32 weeks gestation had skin cleansed with CHG prior to PICC placement. CHG concentrations were measured on serial blood samples. Skin integrity was evaluated for 2 weeks after CHG exposure. RESULT: Twenty infants were enrolled; median gestational age was 28 2/7 weeks (range 24 3/7 to 31 4/7). Ten infants had detectable serum chlorhexidine concentrations (range 1.6 to 206 ng ml(-1)). Seven of these infants had their highest serum concentration 2 to 3 days following exposure. No CHG-related skin irritation occurred in any infant. CONCLUSION: CHG was detected in the blood of preterm infants receiving CHG skin antisepsis for PICC insertion. Highest serum concentrations occurred 2 to 3 days after exposure. Further investigation is needed to determine the clinical relevance of CHG absorption in preterm infants.

引用

页码：768 / 771

页数：4

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