Relationship between oxygen saturation and the mode of oxygen delivery used in newborn resuscitation

Objective: To compare the rate of increase in oxygen saturation in babies receiving supplemental oxygen during resuscitation with those transitioning in room air. Study Design: Prospective observational study. Infants were resuscitated with supplemental oxygen and continuous recording of preductal oxygen saturation was started immediately after birth. Oxygen saturation measurements from healthy newborns transitioned in room air were used for comparison. Result: A total of 186 infants were included-70 received supplemental oxygen and 116 were transitioned in room air. Compared with healthy infants transitioned in room air, infants receiving 100% oxygen by positive-pressure ventilation (PPV) did not differ significantly in the rate of increase in oxygen saturation (1.5% per minute, P=0.26), whereas infants receiving 100% free-flow oxygen had a significantly slower rate of increase in oxygen saturation (1.2% per minute, P=0.04). Conclusion: Babies receiving 100% oxygen by free flow had a slower increase in oxygen saturation compared with healthy infants transitioned in room air, whereas those receiving 100% oxygen by PPV had a similar increase in oxygen saturation compared with healthy infants transitioned in room air.