Cross-Dehydrogenative-Coupling of Alkoxybenzenes with Toluenes: Copper(II) Halide Mediated Tandem Halo/Benzylation of Arenes

被引：12

作者：

Storr, Thomas E. ^{[1
]}

Teskey, Christopher J. ^{[1
]}

Greaney, Michael F. ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Oxford Rd, Manchester M13 9PL, Lancs, England

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 50期

基金：

英国工程与自然科学研究理事会;

关键词：

C-H activation; cross-dehydrogenative-coupling; diarylmethane; homogeneous catalysis; tandem reactions; C-H BOND; CATALYZED DIRECT ARYLATION; SITE-SELECTIVE SP(2); ANTIMICROBIAL ACTIVITIES; METAL-FREE; PALLADIUM; ARYL; FUNCTIONALIZATION; DIARYLMETHANES; BROMOPHENOLS;

D O I：

10.1002/chem.201603783

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A cross-dehydrogenative-coupling of alkoxybenzenes and toluenes with concomitant halogenation is reported. Conditions employed were the use of stoichiometric copper halide salts and dialkylperoxides to afford a range of bromoalkoxydi- and triarylmethanes. Preliminary mechanistic studies suggest that the in situ production of haloarenes (or dihaloarenes) followed by a copper-mediated coupling of a benzylic radical is operational.

引用

页码：18169 / 18178

页数：10

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