Cross-Dehydrogenative-Coupling of Alkoxybenzenes with Toluenes: Copper(II) Halide Mediated Tandem Halo/Benzylation of Arenes

被引：11
作者：
Storr, Thomas E. [1 ]
Teskey, Christopher J. [1 ]
Greaney, Michael F. [1 ]
机构：
[1] Univ Manchester, Sch Chem, Oxford Rd, Manchester M13 9PL, Lancs, England
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 50期
基金：
英国工程与自然科学研究理事会;
关键词：
C-H activation; cross-dehydrogenative-coupling; diarylmethane; homogeneous catalysis; tandem reactions; C-H BOND; CATALYZED DIRECT ARYLATION; SITE-SELECTIVE SP(2); ANTIMICROBIAL ACTIVITIES; METAL-FREE; PALLADIUM; ARYL; FUNCTIONALIZATION; DIARYLMETHANES; BROMOPHENOLS;
D O I：
10.1002/chem.201603783
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A cross-dehydrogenative-coupling of alkoxybenzenes and toluenes with concomitant halogenation is reported. Conditions employed were the use of stoichiometric copper halide salts and dialkylperoxides to afford a range of bromoalkoxydi- and triarylmethanes. Preliminary mechanistic studies suggest that the in situ production of haloarenes (or dihaloarenes) followed by a copper-mediated coupling of a benzylic radical is operational.
引用
收藏
页码：18169 / 18178
页数：10
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