Modulation of protein kinase C isoforms by PAF in cerebral cortex

被引：1

作者：

Calcerrada, MC ^{[1
]}

Pérez-Alvarez, MJ ^{[1
]}

Catalán, RE ^{[1
]}

Martínez, AM ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, Dept Biol Mol, CSIC, Madrid 28049, Spain

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 1999年 / 58卷 / 01期

关键词：

PAF; protein kinase C; cerebral cortex;

D O I：

10.1016/S0090-6980(99)00019-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of platelet activating factor (PAF) on subcellular distribution of protein kinase C isoforms in rat cerebral cortex was investigated. PAF induced an increase in levels of protein kinase C epsilon and gamma in membrane fraction. Results also indicate that PAF induced an increase in protein kinase C delta levels in both cytosolic and membrane fraction. This effect is possibly due to an increase in enzyme synthesis, as indicated by the results obtained from the experiments performed in the presence of cycloheximide and actinomycin. All the effects induced by PAF were time- and dose-dependent, and were mediated through the activation of PAF receptor. These findings indicate that the three isoforms may be involved in signal transduction of PAF in the brain. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：19 / 27

页数：9

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