fMRI reveals cognitive and emotional processing in a long-term comatose patient

被引：34

作者：

Eickhoff, S. B. ^{[1
]}

Dafotakis, M. ^{[1
]}

Grefkes, C. ^{[2
,8
]}

Stoecker, T. ^{[1
]}

Shah, N. J. ^{[1
,4
]}

Schnitzler, A. ^{[5
,6
]}

Zilles, K. ^{[1
,3
,4
,7
]}

Siebler, M.

机构：

[1] Forschungszentrum Julich, Inst Neurowissensch & Biophys Med INB 3, D-52425 Julich, Germany

[2] Max Planck Inst Neurol Res, Cologne, Germany

[3] Univ Dusseldorf, C&O Vogt Inst Brain Res, Dusseldorf, Germany

[4] Brain Imaging Ctr W BICW, Julich, Germany

[5] Univ Dusseldorf, Inst Clin Neurosci & Med Psychol, D-4000 Dusseldorf, Germany

[6] Univ Dusseldorf, Dept Neurol, D-4000 Dusseldorf, Germany

[7] JARA Translat Brain Med, Julich, Germany

[8] Univ Cologne, Dept Neurol, D-5000 Cologne 41, Germany

来源：

EXPERIMENTAL NEUROLOGY | 2008年 / 214卷 / 02期

关键词：

Trauma; Language; Emotion; Persistent vegetative state; Minimally conscious state;

D O I：

10.1016/j.expneurol.2008.08.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We report on a 41-year old woman with prolonged comatose unresponsiveness following traumatic head injury. Structural MRI showed bilateral midbrain damage and ventriculomegalia. Functional MRI revealed robust cortical responses to visual, auditory and tactile stimulation. Speech stimuli moreover consistently elicited activation in Broca's and Wernicke's areas. Familiar speakers and direct addressing evoked significantly stronger amygdala activation than unfamiliar speakers and neutral phrases. This study hence demonstrates the potential of functional neuroimaging in the investigation of residual higher cortical functions in unresponsive comatose patients. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：240 / 246

页数：7

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