68Ga-Triacetylfusarinine C and 68Ga-Ferrioxamine E for Aspergillus Infection Imaging: Uptake Specificity in Various Microorganisms

被引：68

作者：

Petrik, Milos ^{[1
,4
]}

Haas, Hubertus ^{[2
]}

Laverman, Peter ^{[3
]}

Schrettl, Markus ^{[2
]}

Franssen, Gerben M. ^{[3
]}

Blatzer, Michael ^{[2
]}

Decristoforo, Clemens ^{[1
]}

机构：

[1] Med Univ Innsbruck, Clin Dept Nucl Med, A-6020 Innsbruck, Austria

[2] Med Univ Innsbruck, Bioctr, Div Mol Biol, A-6020 Innsbruck, Austria

[3] Radboud Univ Nijmegen, Dept Nucl Med, Med Ctr, NL-6525 ED Nijmegen, Netherlands

[4] Palacky Univ, Fac Med & Dent, Inst Mol & Translat Med, CR-77147 Olomouc, Czech Republic

来源：

MOLECULAR IMAGING AND BIOLOGY | 2014年 / 16卷 / 01期

关键词：

Siderophores; Gallium-68; Infection imaging; Aspergillus fumigatus; Positron emission tomography; INVASIVE PULMONARY ASPERGILLOSIS; IRON UPTAKE; SIDEROPHORES; GA-68-SIDEROPHORES;

D O I：

10.1007/s11307-013-0654-7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Ga-68-triacetylfusarinine C (Ga-68-TAFC) and Ga-68-ferrioxamine E (Ga-68-FOXE) showed excellent targeting properties in Aspergillus fumigatus rat infection model. Here, we report on the comparison of specificity towards different microorganisms and human lung cancer cells (H1299). The in vitro uptake of Ga-68-TAFC and Ga-68-FOXE was studied in various fungal, bacterial and yeast cultures as well as in H1299 cells. The in vivo imaging was studied in fungal and bacterial rat infection and inflammation models. Ga-68-TAFC and Ga-68-FOXE showed rapid uptake in A. fumigatus cultures, significantly lower in other fungal species and almost no uptake in other microorganisms and H1299 cells, except for Ga-68-FOXE in Staphylococcus aureus. Ga-68-TAFC and Ga-68-FOXE revealed rapid uptake in the lungs of A. fumigatus-infected rats, low accumulation in sterile inflammation and no uptake in bacterial abscess. We have shown that Ga-68-FOXE and Ga-68-TAFC have high uptake in A. fumigatus both in vitro and in vivo. Ga-68-TAFC showed higher specificity, while Ga-68-FOXE showed higher sensitivity.

引用

页码：102 / 108

页数：7

共 26 条

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