EFFECT OF DOPAMINE RECEPTORS (D1 AND D2) DOWN-REGULATION IN BASOLATERAL AMYGDALA ON CONDITIONED DEFENSIVE BEHAVIOR OF RATS

被引：0

作者：

Pavlova, I. V. ^{[1
]}

Rysakova, M. P. ^{[1
]}

Spivak, J. S. ^{[1
]}

Broshevitskaya, N. D. ^{[1
]}

Aksenova, J. V. ^{[1
]}

Salozhin, S. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Higher Nervous Activ & Neurophysiol, Moscow, Russia

来源：

ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA | 2019年 / 69卷 / 02期

关键词：

amygdala; auditory fear conditioning; passive avoidance; search of the hidden platform in the Morris water maze; dopamine receptor (D1R and D2R); lentiviral transduction; RNA-interference; PASSIVE-AVOIDANCE; FEAR; NEURONS; D-1; MEMORY; INVOLVEMENT; EXPRESSION; BLOCKADE; ANXIETY; INTERNEURONS;

D O I：

10.1134/S0044467719020102

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of amygdalar dopamine receptors (D1R and D2R) down-regulation on the behavior in different conditioned defensive paradigms were investigated using lentiviral-mediated RNA interference. Immunohistochemical staining showed that lentiviral vectors were expressed in both neurons (average 19%) and astrocytes (73%). Downregulation of D1R impaired acquisition and accelerated extinction of auditory fear conditioning, facilitated passive avoidance extinction. At the beginning of learning in the Morris water maze, rats with D1R reduction failed more frequently to find the hidden platform compared to control animals. The behavior of rats with high freezing level was more impacted than animals with low freezing level by D1R downregulation in amygdala. Down regulation of D2R facilitated extinction of auditory fear conditioning and passive avoidance. The results indicate different role of amygdalar D1R and D2R, D1R, in contrast to D2R, plays an important role in the aversive learning and in the expression of conditioned fear in the form of longlasting freezing. D1R and D2R in amygdala are essential for fear retention to extinction.

引用

页码：194 / 210

页数：17

共 47 条

[1]

Almaguer W, 2005, RESTOR NEUROL NEUROS, V23, P43

[2] D1 and D2 dopaminergic systems in the rat basolateral amygdala are involved in anxiogenic-like effects induced by histamine [J].

Bananej, Maryam ;

Karimi-Sori, Ahmad ;

Zarrindast, Mohammad Reza ;

Ahmadi, Shamseddin .

JOURNAL OF PSYCHOPHARMACOLOGY, 2012, 26 (04) :564-574

[3] Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia [J].

Cakir, Tunahan ;

Alsan, Selma ;

Saybasili, Hale ;

Akin, Ata ;

Ulgen, Kutlu O. .

THEORETICAL BIOLOGY AND MEDICAL MODELLING, 2007, 4

[4] Target-Specific Suppression of GABA Release from Parvalbumin Interneurons in the Basolateral Amygdala by Dopamine [J].

Chu, Hong-Yuan ;

Ito, Wataru ;

Li, Jiayang ;

Morozov, Alexei .

JOURNAL OF NEUROSCIENCE, 2012, 32 (42) :14815-14820

[5] Viral delivery of shRNA to amygdala neurons leads to neurotoxicity and deficits in Pavlovian fear conditioning [J].

de Solis, Christopher A. ;

Holehonnur, Roopashri ;

Banerjee, Anwesha ;

Luong, Jonathan A. ;

Lella, Srihari K. ;

Ho, Anthony ;

Pahlavan, Bahram ;

Ploski, Jonathan E. .

NEUROBIOLOGY OF LEARNING AND MEMORY, 2015, 124 :34-47

[6]

Dubrovina NI, 2008, ZH VYSSH NERV DEYAT+, V58, P605

[7]

Dubrovina NI, 2005, ZH VYSSH NERV DEYAT+, V55, P543

[8] Cell-type specific deletion of GABA(A)α1 in corticotropin-releasing factor-containing neurons enhances anxiety and disrupts fear extinction [J].

Gafford, Georgette M. ;

Guo, Ji-Dong ;

Flandreau, Elizabeth I. ;

Hazra, Rimi ;

Rainnie, Donald G. ;

Ressler, Kerry J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (40) :16330-16335

[9] Enhancement of spatial learning by predator odor in mice: Involvement of amygdala and hippocampus [J].

Galliot, Emmanuel ;

Levaillant, Maryline ;

Beard, Elidie ;

Millot, Jean-Louis ;

Pourie, Gregory .

NEUROBIOLOGY OF LEARNING AND MEMORY, 2010, 93 (02) :196-202

[10] Peripheral and intraamygdalar administration of the dopamine D1 receptor antagonist SCH 23390 blocks fear-potentiated startle but not shock reactivity or the shock sensitization of acoustic startle [J].

Greba, Q ;

Kokkinidis, L .

BEHAVIORAL NEUROSCIENCE, 2000, 114 (02) :262-272

← 1 2 3 4 5 →