Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants

被引：29
|
作者：
Kim, Sungjune [1 ]
Lalani, Saif [1 ]
Parekh, Vrajesh V. [1 ]
Wu, Lan [1 ]
Van Kaer, Luc [1 ]
机构：
[1] Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37232 USA
来源：
EXPERT REVIEW OF VACCINES | 2008年 / 7卷 / 10期
关键词：
alpha-galactosylceramide; adjuvant; antigen presentation; CD1d; glycolipid; innate immunity; invariant natural killer T cell;
D O I：
10.1586/14760584.7.10.1519
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Invariant natural killer T(iNKT) cells area unique subset of T lymphocytes that recognize glycolipid antigens in the context of the antigen-presenting molecule CD1d. Upon glycolipid antigen stimulation, iNKT cells rapidly produce copious amounts of immunomodulatory cytokines, leading to potent activation of a variety of innate and adaptive immune cells. These immune-potentiating properties of iNKT cells hold great promise for the development of vaccine adjuvants. This review aims to summarize the immunomodulatory activities of iNKT cell ligands and to discuss prospects for developing iNKT cell-based vaccine adjuvants.
引用
收藏
页码：1519 / 1532
页数：14
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