Genetic contributions to pain: a review of findings in humans

被引：83

作者：

Fillingim, R. B. ^{[1
,3
]}

Wallace, M. R. ^{[2
]}

Herbstman, D. M. ^{[2
]}

Ribeiro-Dasilva, M. ^{[1
]}

Staud, R. ^{[2
]}

机构：

[1] Univ Florida, Coll Dent, Gainesville, FL 32608 USA

[2] Univ Florida, Coll Med, Gainesville, FL 32608 USA

[3] N Florida S Georgia Vet Hlth Syst, Gainesville, FL USA

来源：

ORAL DISEASES | 2008年 / 14卷 / 08期

关键词：

pain; genetics; pain sensitivity; chronic pain; orofacial pain;

D O I：

10.1111/j.1601-0825.2008.01458.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Pain represents the major motivating factor for which individuals seek healthcare, and pain responses are characterized by substantial inter-individual differences. Increasing evidence suggests that genetic factors contribute significantly to individual differences in responses to both clinical and experimental pain. The purpose of this review article was to summarize the current literature regarding genetic contributions to pain, highlighting findings relevant to oral pain where available. A brief discussion of methodologic considerations is followed by a review of findings regarding genetic influences on clinical pain. Next, the literature examining genetic contributions to experimental pain responses is presented, emphasizing genetic associations that have been replicated in multiple cohorts. It is hoped that an enhanced understanding of genetic contributions to pain responses will ultimately improve diagnosis and treatment of clinical pain conditions. Oral Diseases (2008) 14, 673-682

引用

页码：673 / 682

页数：10

共 110 条

[1]

Ablin JN, 2005, ARTHRITIS RHEUM-US, V52, pS269

[2] Atypical facial pain: clinical considerations and differential diagnosis [J].

Agostoni, E ;

Frigerio, R ;

Santoro, P .

NEUROLOGICAL SCIENCES, 2005, 26 (Suppl 2) :S71-S74

[3] Family study of fibromyalgia [J].

Arnold, LM ;

Hudson, JI ;

Hess, EV ;

Ware, AE ;

Fritz, DA ;

Auchenbach, MB ;

Starck, LO ;

Keck, PE .

ARTHRITIS AND RHEUMATISM, 2004, 50 (03) :944-952

[4] Relationships between measurement of pain using visual analog score and morphine requirements during postoperative intravenous morphine titration [J].

Aubrun, F ;

Langeron, O ;

Quesnel, C ;

Coriat, P ;

Riou, B .

ANESTHESIOLOGY, 2003, 98 (06) :1415-1421

[5] Heritability of low back pain and the role of disc degeneration [J].

Battie, Michele C. ;

Videman, Tapio ;

Levalahti, Esko ;

Gill, Kevin ;

Kaprio, Jaakko .

PAIN, 2007, 131 (03) :272-280

[6] Candidate gene studies of human pain mechanisms - Methods for optimizing choice of polymorphisms and sample size [J].

Belfer, I ;

Wu, TX ;

Kingman, A ;

Krishnaraju, RK ;

Goldman, D ;

Max, MB .

ANESTHESIOLOGY, 2004, 100 (06) :1562-1572

[7] Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor [J].

Beyer, A ;

Koch, T ;

Schröder, H ;

Schulz, S ;

Höllt, V .

JOURNAL OF NEUROCHEMISTRY, 2004, 89 (03) :553-560

[8]

BIGOS SJ, 1992, CLIN ORTHOP RELAT R, P21

[9] Characteristics and prediction of early pain after laparoscopic cholecystectomy [J].

Bisgaard, T ;

Klarskov, B ;

Rosenberg, J ;

Kehlet, H .

PAIN, 2001, 90 (03) :261-269

[10] Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity:: Possible implications for opiate addiction [J].

Bond, C ;

LaForge, KS ;

Tian, MT ;

Melia, D ;

Zhang, SW ;

Borg, L ;

Gong, JH ;

Schluger, J ;

Strong, JA ;

Leal, SM ;

Tischfield, JA ;

Kreek, MJ ;

Yu, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (16) :9608-9613

← 1 2 3 4 5 6 7 8 9 10 →