On the interactions between mesenchymal stem cells and regulatory T cells for immunomoculation in transplantation

被引：59

作者：

Engela, Anja U. ^{[1
]}

Baan, Carla C. ^{[1
]}

Dor, Frank J. M. F. ^{[2
]}

Weimar, Willem ^{[1
]}

Hoogduijn, Martin J. ^{[1
]}

机构：

[1] Univ Med Ctr, Erasmus MC, Dept Internal Med, Transplantat Lab, NL-3000 CA Rotterdam, Netherlands

[2] Univ Med Ctr, Erasmus MC, Dept Surg, Rotterdam, Netherlands

来源：

FRONTIERS IN IMMUNOLOGY | 2012年 / 3卷

关键词：

mesenchymal stem cell; regulatory T cell; transplantation; VERSUS-HOST-DISEASE; HUMAN ADIPOSE-TISSUE; BONE-MARROW; STROMAL CELLS; GENE-EXPRESSION; KIDNEY-TRANSPLANTATION; IMMUNE DYSREGULATION; PROSTAGLANDIN E-2; CUTTING EDGE; HUMAN HEART;

D O I：

10.3389/fimmu.2012.00126

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Experimental studies have established the use of mesenchymal stem cells (MSC) as a candidate immunosuppressive therapy. MSC exert their immunomodulatory function through the inhibition of CD4(+) and CD8(+) T cell proliferation. It is unknown whether MSC impair the immunosuppressive function of regulatory T cells (Treg). In vitro and in vivo studies suggest that MSC mediate their immunomodulatory effects through the induction of Treg. In this review we will focus on the interactions between MSC and Treg, and evaluate the consequences of these cellular interplays for prospective MSC immunotherapy in organ transplantation.

引用

页数：8

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