On the interactions between mesenchymal stem cells and regulatory T cells for immunomoculation in transplantation

被引：59

作者：

Engela, Anja U. ^{[1
]}

Baan, Carla C. ^{[1
]}

Dor, Frank J. M. F. ^{[2
]}

Weimar, Willem ^{[1
]}

Hoogduijn, Martin J. ^{[1
]}

机构：

[1] Univ Med Ctr, Erasmus MC, Dept Internal Med, Transplantat Lab, NL-3000 CA Rotterdam, Netherlands

[2] Univ Med Ctr, Erasmus MC, Dept Surg, Rotterdam, Netherlands

来源：

FRONTIERS IN IMMUNOLOGY | 2012年 / 3卷

关键词：

mesenchymal stem cell; regulatory T cell; transplantation; VERSUS-HOST-DISEASE; HUMAN ADIPOSE-TISSUE; BONE-MARROW; STROMAL CELLS; GENE-EXPRESSION; KIDNEY-TRANSPLANTATION; IMMUNE DYSREGULATION; PROSTAGLANDIN E-2; CUTTING EDGE; HUMAN HEART;

D O I：

10.3389/fimmu.2012.00126

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Experimental studies have established the use of mesenchymal stem cells (MSC) as a candidate immunosuppressive therapy. MSC exert their immunomodulatory function through the inhibition of CD4(+) and CD8(+) T cell proliferation. It is unknown whether MSC impair the immunosuppressive function of regulatory T cells (Treg). In vitro and in vivo studies suggest that MSC mediate their immunomodulatory effects through the induction of Treg. In this review we will focus on the interactions between MSC and Treg, and evaluate the consequences of these cellular interplays for prospective MSC immunotherapy in organ transplantation.

引用

页数：8

共 103 条

[21] Inflammatory conditions affect gene expression and function of human adipose tissue-derived mesenchymal stem cells [J].

Crop, M. J. ;

Baan, C. C. ;

Korevaar, S. S. ;

IJzermans, J. N. M. ;

Pescatori, M. ;

Stubbs, A. P. ;

van IJcken, W. F. J. ;

Dahlke, M. H. ;

Eggenhofer, E. ;

Weimar, W. ;

Hoogduijn, M. J. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2010, 162 (03) :474-486

[22] Myogenic Properties of Human Mesenchymal Stem Cells Derived From Three Different Sources [J].

de la Garza-Rodea, Anabel S. ;

van der Velde-van Dijke, Ietje ;

Boersma, Hester ;

Goncalves, Manuel A. F. V. ;

van Bekkum, Dirk W. ;

de Vries, Antoine A. F. ;

Knaan-Shanzer, Shoshan .

CELL TRANSPLANTATION, 2012, 21 (01) :153-173

[23] Immunogenicity and Immunomodulatory Properties of Umbilical Cord Lining Mesenchymal Stem Cells [J].

Deuse, Tobias ;

Stubbendorff, Mandy ;

Tang-Quan, Karis ;

Phillips, Neil ;

Kay, Mark A. ;

Eiermann, Thomas ;

Phan, Thang T. ;

Volk, Hans-Dieter ;

Reichenspurner, Hermann ;

Robbins, Robert C. ;

Schrepfer, Sonja .

CELL TRANSPLANTATION, 2011, 20 (05) :655-667

[24] Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation [J].

Di Ianni, Mauro ;

Falzetti, Franca ;

Carotti, Alessandra ;

Terenzi, Adelmo ;

Castellino, Flora ;

Bonifacio, Elisabetta ;

Del Papa, Beatrice ;

Zei, Tiziana ;

Ostini, Roberta Iacucci ;

Cecchini, Debora ;

Aloisi, Teresa ;

Perruccio, Katia ;

Ruggeri, Loredana ;

Balucani, Chiara ;

Pierini, Antonio ;

Sportoletti, Paolo ;

Aristei, Cynthia ;

Falini, Brunangelo ;

Reisner, Yair ;

Velardi, Andrea ;

Aversa, Franco ;

Martelli, Massimo F. .

BLOOD, 2011, 117 (14) :3921-3928

[25] Mesenchymal cells recruit and regulate T regulatory cells [J].

Di Lanni, Mauro ;

Del Papa, Beatrice ;

De Loanni, Maria ;

Moretti, Lorenzo ;

Bonifacio, Elisabetta ;

Cecchini, Debora ;

Sportoletti, Paolo ;

Falzetti, Franca ;

Tabilio, Antonio .

EXPERIMENTAL HEMATOLOGY, 2008, 36 (03) :309-318

[26] Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli [J].

Di Nicola, M ;

Carlo-Stella, C ;

Magni, M ;

Milanesi, M ;

Longoni, PD ;

Matteucci, P ;

Grisanti, S ;

Gianni, AM .

BLOOD, 2002, 99 (10) :3838-3843

[27] Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement [J].

Dominici, M. ;

Le Blanc, K. ;

Mueller, I. ;

Slaper-Cortenbach, I. ;

Marini, F. C. ;

Krause, D. S. ;

Deans, R. J. ;

Keating, A. ;

Prockop, D. J. ;

Horwitz, E. M. .

CYTOTHERAPY, 2006, 8 (04) :315-317

[28] Features of synergism between mesenchymal stem cells and immunosuppressive drugs in a murine heart transplantation model [J].

Eggenhofer, Elke ;

Renner, Philipp ;

Soeder, Yorick ;

Popp, Felix C. ;

Hoogduijn, Martin J. ;

Geissler, Edward K. ;

Schlitt, Hans J. ;

Dahlke, Marc H. .

TRANSPLANT IMMUNOLOGY, 2011, 25 (2-3) :141-147

[29] Interaction Between Adipose Tissue-Derived Mesenchymal Stem Cells and Regulatory T-Cells [J].

Engela, Anja U. ;

Baan, Carla C. ;

Peeters, Annemiek M. A. ;

Weimar, Willem ;

Hoogduijn, Martin J. .

CELL TRANSPLANTATION, 2013, 22 (01) :41-54

[30] Cell contact, prostaglandin E2 and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25Highforkhead box P3+ regulatory T cells [J].

English, K. ;

Ryan, J. M. ;

Tobin, L. ;

Murphy, M. J. ;

Barry, F. P. ;

Mahon, B. P. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2009, 156 (01) :149-160

← 1 2 3 4 5 6 7 8 9 10 →