Metformin and cancer

被引：128

作者：

Rizos, Christos V. ^{[1
]}

Elisaf, Moses S. ^{[1
]}

机构：

[1] Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2013年 / 705卷 / 1-3期

关键词：

Metformin; Cancer; Neoplasm; Diabetes; Pleiotropic effects; Mortality; DEPENDENT DIABETES-MELLITUS; INTESTINAL GLUCOSE-ABSORPTION; NUTRITION EXAMINATION SURVEY; PREVENTION PROGRAM OUTCOMES; ACTIVATED PROTEIN-KINASE; IMPAIRED FASTING GLUCOSE; POPULATION-BASED COHORT; ALL-CAUSE MORTALITY; EARLY BREAST-CANCER; HEPATOCELLULAR-CARCINOMA;

D O I：

10.1016/j.ejphar.2013.02.038

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Type 2 diabetes mellitus is a rising cause of cardiovascular morbidity and mortality. A number of studies have also identified diabetic patients as having increased risk for the development of cancer. Metformin is a widely prescribed antidiabetic drug with an established efficacy coupled with a favorable safety profile and low cost. An increasing number of studies have associated metformin treatment with a decrease of cancer risk. Moreover, metformin has also been associated with improved outcomes in cancer patients. These possible pleiotropic effects of metformin may establish metformin as a cancer prevention and treatment option. However, any favorable effects of metformin on cancer are not always corroborated by clinical trials. Larger studies are expected to better investigate the possible antineoplastic effects of metformin. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：96 / 108

页数：13

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