anticancer drugs;
imaging techniques;
living cells;
medicinal chemistry;
Raman spectroscopy;
CANCER-CELL-LINES;
MICRO-SPECTROSCOPY;
SINGLE CELLS;
LIVING CELLS;
MICROSPECTROSCOPY;
IDENTIFICATION;
D O I:
10.1002/cphc.201200800
中图分类号:
O64 [物理化学(理论化学)、化学物理学];
学科分类号:
070304 ;
081704 ;
摘要:
There is an urgent need for methods allowing for a fast, non-invasive, sensitive and selective monitoring of the effectiveness of anticancer drugs during the course of a chemotherapeutic treatment of cancer patients. The possibility of predicting and controlling the efficiency of chemotherapeutic agents for every patient individually enables a personalized therapy with largely improved success rates. The results presented herein demonstrate that Raman microspectroscopy is perfectly suited to monitor the impact of chemotherapeutic agents on living cells. The influence of the clinically well-established chemotherapeutic docetaxel on both the morphology and also biochemistry of living colon cancer cells (HT-29) has been studied by means of Raman spectroscopy in combination with modern chemometric approaches. The work presented paves the way for establishing Raman spectroscopy as a monitoring tool of the effectiveness of a chemotherapy treatment and can therefore be seen as a step towards personalized therapy.
机构:
Univ Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, FranceUniv Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, France
Draux, Florence
;
Gobinet, Cyril
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, FranceUniv Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, France
Gobinet, Cyril
;
Sule-Suso, Josep
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp N Staffordshire, Ctr Canc, City Gen Hosp, Stoke On Trent ST4 6QG, Staffs, England
Keele Univ, Inst Sci & Technol Med, Guy Hilton Res Ctr, Stoke On Trent ST4 7QB, Staffs, EnglandUniv Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, France
Sule-Suso, Josep
;
Manfait, Michel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, FranceUniv Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, France
Manfait, Michel
;
Jeannesson, Pierre
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, FranceUniv Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, France
Jeannesson, Pierre
;
Sockalingum, Ganesh D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, FranceUniv Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, France
机构:
Univ Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, FranceUniv Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, France
Draux, Florence
;
Jeannesson, Pierre
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, FranceUniv Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, France
Jeannesson, Pierre
;
Beljebbar, Abdelilah
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, FranceUniv Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, France
Beljebbar, Abdelilah
;
Tfayli, Ali
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, FranceUniv Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, France
Tfayli, Ali
;
Fourre, Nicolas
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, FranceUniv Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, France
Fourre, Nicolas
;
Manfait, Michel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, FranceUniv Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, France
Manfait, Michel
;
Sule-Suso, Josep
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp N Staffordshire, Staffordshire Oncol Ctr, Stoke On Trent, Staffs, England
Keele Univ, Stoke On Trent, Staffs, EnglandUniv Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, France
Sule-Suso, Josep
;
Sockalingum, Ganesh D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, FranceUniv Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, France
机构:
Univ Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, FranceUniv Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, France
Draux, Florence
;
Gobinet, Cyril
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, FranceUniv Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, France
Gobinet, Cyril
;
Sule-Suso, Josep
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp N Staffordshire, Ctr Canc, City Gen Hosp, Stoke On Trent ST4 6QG, Staffs, England
Keele Univ, Inst Sci & Technol Med, Guy Hilton Res Ctr, Stoke On Trent ST4 7QB, Staffs, EnglandUniv Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, France
Sule-Suso, Josep
;
Manfait, Michel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, FranceUniv Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, France
Manfait, Michel
;
Jeannesson, Pierre
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, FranceUniv Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, France
Jeannesson, Pierre
;
Sockalingum, Ganesh D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, FranceUniv Reims, Equipe MeDIAN, UFR Pharm, IFR53,UMR MEDyC 6237, F-51096 Reims, France
机构:
Univ Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, FranceUniv Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, France
Draux, Florence
;
Jeannesson, Pierre
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, FranceUniv Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, France
Jeannesson, Pierre
;
Beljebbar, Abdelilah
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, FranceUniv Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, France
Beljebbar, Abdelilah
;
Tfayli, Ali
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, FranceUniv Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, France
Tfayli, Ali
;
Fourre, Nicolas
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, FranceUniv Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, France
Fourre, Nicolas
;
Manfait, Michel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, FranceUniv Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, France
Manfait, Michel
;
Sule-Suso, Josep
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp N Staffordshire, Staffordshire Oncol Ctr, Stoke On Trent, Staffs, England
Keele Univ, Stoke On Trent, Staffs, EnglandUniv Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, France
Sule-Suso, Josep
;
Sockalingum, Ganesh D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, FranceUniv Reims, CNRS, UMR 6237, Unite MeDIAN,UFR Pharm,IFR53, F-51096 Reims, France