Biomimetic Aerobic Oxidation of Amino Alcohols to Lactams

被引：32

作者：

Babu, Beneesh P. ^{[1
]}

Endo, Yoshinori ^{[1
]}

Backvall, Jan-E. ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2012年 / 18卷 / 37期

基金：

欧洲研究理事会;

关键词：

amino alcohols; biomimetic synthesis; lactams; oxidation; ruthenium; MULTISTEP ELECTRON-TRANSFER; COUPLED CATALYTIC-SYSTEM; HYDROGEN-TRANSFER; AMIDE SYNTHESIS; RUTHENIUM; ALDEHYDES; DEHYDROGENATION; COMPLEXES; COBALT; AMINOCARBONYLATION;

D O I：

10.1002/chem.201202080

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The right path: N-Protected amino alcohols undergo aerobic and biomimetic oxidation to the corresponding lactams in the presence of a ruthenium catalyst and a combination of electron-transfer mediators under air (see scheme). The reaction was used for the synthesis of five-, six-, and seven-, membered lactams and showed good tolerance to a number of N-protecting groups. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：11524 / 11527

页数：4

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