Clinical utility of calprotectin and lactoferrin in patients with inflammatory bowel disease: is there something new from the literature?

被引：11

作者：

Caccaro, Roberta ^{[1
]}

D'Inca, Renata ^{[1
]}

Pathak, Surajit ^{[1
]}

Sturniolo, Giacomo Carlo ^{[1
]}

机构：

[1] Univ Padua, Dept Surg Oncol & Gastroenterol Sci, I-35128 Padua, Italy

来源：

EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2012年 / 8卷 / 06期

关键词：

calprotectin; disease markers; fecal markers; inflammatory bowel disease; lactoferrin; FECAL CALPROTECTIN; CROHNS-DISEASE; INFLIXIMAB RESPONDERS; ULCERATIVE-COLITIS; SURROGATE MARKERS; RAPID TEST; DIAGNOSIS; CHILDREN; RELAPSE; PREDICTION;

D O I：

10.1586/ECI.12.50

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The identification of noninvasive biomarkers is still one of the major issue for gastroenterologists dealing with inflammatory bowel disease patients, due to the chronicity of these conditions and the early onset of symptoms in the majority of cases. Research attention has focused mainly on fecal proteins, especially calprotectin and lactoferrin, and most of the published data are reassuring about their applicability in the diagnosis and monitoring of these patients. However, there are still pending questions regarding the reliability of fecal proteins especially in the era of mucosal healing and biologics.

引用

页码：579 / 585

页数：7

共 37 条

[1] Surrogate markers and clinical indices, alone or combined, as indicators for endoscopic remission in anti-TNF-treated luminal Crohn's disease [J].

af Bjorkesten, Clas-Goran ;

Nieminen, Urpo ;

Turunen, Ulla ;

Arkkila, Perttu ;

Sipponen, Taina ;

Farkkila, Martti .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2012, 47 (05) :528-537

[2] Fecal Calprotectin Is a Useful Marker for Disease Activity in Pediatric Patients with Inflammatory Bowel Disease [J].

Aomatsu, Tomoki ;

Yoden, Atsushi ;

Matsumoto, Kyoichi ;

Kimura, Emi ;

Inoue, Keisuke ;

Andoh, Akira ;

Tamai, Hiroshi .

DIGESTIVE DISEASES AND SCIENCES, 2011, 56 (08) :2372-2377

[3]

Caccaro R, 2010, EXPERT REV CLIN IMMU, V6, P551, DOI [10.1586/eci.10.26, 10.1586/ECI.10.26]

[4] Fecal calprotectin is a surrogate marker for endoscopic lesions in inflammatory bowel disease [J].

D'Haens, Geert ;

Ferrante, Marc ;

Vermeire, Severine ;

Baert, Filip ;

Noman, Maja ;

Moortgat, Liesbeth ;

Geens, Patricia ;

Iwens, Doreen ;

Aerden, Isolde ;

Van Assche, Gert ;

Van Olmen, Gust ;

Rutgeerts, Paul .

INFLAMMATORY BOWEL DISEASES, 2012, 18 (12) :2218-2224

[5]

Dave Maneesh, 2012, Gastroenterol Hepatol (N Y), V8, P29

[6] Fast and sharp decrease in calprotectin predicts remission by infliximab in anti-TNF naive patients with ulcerative colitis [J].

De Vos, M. ;

Dewit, O. ;

D'Haens, G. ;

Baert, F. ;

Fontaine, F. ;

Vermeire, S. ;

Franchimont, D. ;

Moreels, T. ;

Staessen, D. ;

Terriere, L. ;

Vander Cruyssen, B. ;

Louis, E. .

JOURNAL OF CROHNS & COLITIS, 2012, 6 (05) :557-562

[7] Prediction of Crohn's disease relapse with faecal calprotectin in infliximab responders: a prospective study [J].

Deshpande, A. R. ;

Strobel, S. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2011, 34 (05) :586-586

[8] Diagnostic Work-up of Inflammatory Bowel Disease in Children: The Role of Calprotectin Assay [J].

Diamanti, A. ;

Panetta, F. ;

Basso, M. S. ;

Forgione, A. ;

Colistro, F. ;

Bracci, F. ;

Papadatou, B. ;

Francalanci, P. ;

Torroni, F. ;

Knafelz, D. ;

Fina, F. ;

Castro, M. .

INFLAMMATORY BOWEL DISEASES, 2010, 16 (11) :1926-1930

[9] Comparative study of a new quantitative rapid test with an established ELISA method for faecal calprotectin [J].

Dolci, Alberto ;

Panteghini, Mauro .

CLINICA CHIMICA ACTA, 2012, 413 (1-2) :350-351

[10] Does fecal calprotectin predict relapse in patients with Crohn's disease and ulcerative colitis? [J].

Garcia-Sanchez, Valle ;

Iglesias-Flores, Eva ;

Gonzalez, Raul ;

Gisbert, Javier P. ;

Maria Gallardo-Valverde, Jose ;

Gonzalez-Galilea, Angel ;

Naranjo-Rodriguez, Antonio ;

de Dios-Vega, Juan F. ;

Muntane, Jordi ;

Gomez-Camacho, Federico .

JOURNAL OF CROHNS & COLITIS, 2010, 4 (02) :144-152

← 1 2 3 4 →