Personalized targeted therapy for esophageal squamous cell carcinoma

被引：47

作者：

Kang, Xiaozheng ^{[1
]}

Chen, Keneng ^{[1
]}

Li, Yicheng ^{[2
]}

Li, Jianying ^{[3
]}

D'Amico, Thomas A. ^{[4
]}

Chen, Xiaoxin ^{[2
,5
]}

机构：

[1] Peking Univ, Canc Hosp & Inst, Dept Thorac Surg 1, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

[2] N Carolina Cent Univ, Julius L Chambers Biomed Biotechnol Res Inst, Canc Res Program, Durham, NC 27707 USA

[3] Euclados Bioinformat Solut LLC, Cary, NC 27519 USA

[4] Duke Univ, Med Ctr, Div Thorac Surg, Durham, NC 27705 USA

[5] Univ N Carolina, Ctr Esophageal Dis & Swallowing, Dept Med, Div Gastroenterol & Hepatol, Chapel Hill, NC 27519 USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2015年 / 21卷 / 25期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

Cancer heterogeneity; Cultured tumor cells; Driver mutation; Drug side effects; Esophageal squamous cell carcinoma; Exceptional responder; High-throughput nucleotide sequencing; Neoplasm drug resistance; Personalized medicine; Xenograft model; PATHWAY-BASED CLASSIFICATION; CANCER DRIVER GENES; ACQUIRED-RESISTANCE; LUNG ADENOCARCINOMAS; MOUSE MODELS; LYMPH-NODE; GENOME; MUTATIONS; PATIENT; CHEMOTHERAPY;

D O I：

10.3748/wjg.v21.i25.7648

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Esophageal squamous cell carcinoma continues to heavily burden clinicians worldwide. Researchers have discovered the genomic landscape of esophageal squamous cell carcinoma, which holds promise for an era of personalized oncology care. One of the most pressing problems facing this issue is to improve the understanding of the newly available genomic data, and identify the driver-gene mutations, pathways, and networks. The emergence of a legion of novel targeted agents has generated much hope and hype regarding more potent treatment regimens, but the accuracy of drug selection is still arguable. Other problems, such as cancer heterogeneity, drug resistance, exceptional responders, and side effects, have to be surmounted. Evolving topics in personalized oncology, such as interpretation of genomics data, issues in targeted therapy, research approaches for targeted therapy, and future perspectives, will be discussed in this editorial.

引用

页码：7648 / 7658

页数：11

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