18F Labeling of Arenes

被引：204

作者：

Tredwell, Matthew ^{[1
]}

Gouverneur, Veronique ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 46期

基金：

英国工程与自然科学研究理事会;

关键词：

aryl fluorides; fluorine-18; heterocycles; positron emission tomography; radiochemistry; POSITRON-EMISSION-TOMOGRAPHY; NUCLEOPHILIC AROMATIC-SUBSTITUTION; DIRECT ELECTROPHILIC RADIOFLUORINATION; HETEROAROMATIC IODONIUM SALTS; F-18-LABELED ARYL FLUORIDES; IN-VIVO EVALUATION; DIARYLIODONIUM-SALTS; F-18; FLUORIDE; AUTOMATED SYNTHESIS; ELECTROCHEMICAL RADIOFLUORINATION;

D O I：

10.1002/anie.201204687

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Molecular imaging has witnessed an upsurge in growth, with positron emission tomography leading the way. This trend has encouraged numerous synthetic chemists to enter the field of 18F-radiochemistry and provide generic solutions to address the well-recognized challenges of late-stage fluorination. This Minireview focuses on recent developments in the 18F-labeling of aromatic substrates.

引用

页码：11426 / 11437

页数：12

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