Cell Responses to Growth Factors: The Role of Receptor Tyrosine Kinase Intracellular Domain Fragments

被引：6

作者：

Carpenter, Graham ^{[1
]}

Pozzi, Ambra ^{[2
]}

机构：

[1] Vanderbilt Univ, Dept Biochem, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Dept Med, Nashville, TN 37232 USA

来源：

SCIENCE SIGNALING | 2012年 / 5卷 / 243期

关键词：

REGULATED INTRAMEMBRANE PROTEOLYSIS; MAMMARY EPITHELIAL-CELLS; GAMMA-SECRETASE; CANCER-CELLS; CLEAVAGE; ACTIVATION; ERBB4; PROLIFERATION; MIGRATION; DIFFERENTIATION;

D O I：

10.1126/scisignal.2003526

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Growth factor activation of receptor tyrosine kinases (RTKs) provokes well-described canonical second messenger pathways that transmit biochemical signals in the cytoplasm and to the nucleus to initiate cellular responses. The proteolytic liberation of intracellular domain fragments (ICDs) from activated RTKs and the nuclear translocation of these ICDs represent a more recently identified and noncanonical mechanism by which RTKs communicate with the nucleus. Several reports have added previously unknown facets to the ICD mechanism and have enlarged the scope of ICDs as second messengers.

引用

页数：4

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