Advances in steady-state continuous-flow purification by small-scale free-flow electrophoresis

被引：25

作者：

Agostino, Fletcher J. ^{[1
]}

Krylov, Sergey N. ^{[1
]}

机构：

[1] York Univ, Ctr Res Biomol Interact, Toronto, ON M3J 2R7, Canada

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2015年 / 72卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

Continuous-flow chemistry; Continuous-flow purification; Electrolysis; Free-flow electrophoresis; Free-flow fractionation; Liquid-liquid extraction; Magnetophoresis; Purification; Separation; Steady state; LIQUID-LIQUID-EXTRACTION; ZONE ELECTROPHORESIS; MICROFLUIDIC CHANNELS; ESCHERICHIA-COLI; HIGH-TEMPERATURE; SEPARATION; MICRO; SYSTEM; DEVICE; RESOLUTION;

D O I：

10.1016/j.trac.2015.03.023

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This year marks the 150th anniversary of the first continuous-flow chemistry (CFC) technique, developed by Ernest Solvay, which revolutionized industrial level synthesis. CFC is defined by multi-stage processes in which mixing and reacting of chemicals occur without interruption. A significant challenge of CFC lies in post-reaction purification. Free-flow electrophoresis (FFE) could be integrated with CFC. FFE separates chemicals by an electric field that is directed orthogonally to a pressure driven hydrodynamic flow. Although there are problems with FFE, both macro-scale and small-scale FFE are feasible for CFC integration, and realizing long-term steady-state continuous-flow purification can have significant benefits. In this review, we discuss (i) the progress of CFC, (ii) existing continuous-flow purification techniques, (iii) small-scale FFE limitations associated with steady-state continuous-flow purification, and (iv) advances in FFE performance. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：68 / 79

页数：12

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