Recent development on naphthoquinone derivatives and their therapeutic applications as anticancer agents

被引：85
作者：
Tandon, Vishnu Kumar [1 ]
Kumar, Sandeep [2 ]
机构：
[1] GB Tech Univ, Inst Engn & Technol, Dept Appl Sci, Lucknow, Uttar Pradesh, India
[2] Univ Lucknow, Dept Chem, Lucknow 226007, Uttar Pradesh, India
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 2013年 / 23卷 / 09期
关键词：
1,2-naphthoquinone; 1,4-naphthoquinone; anticancer; apoptosis; cancer cell lines; cytotoxic; MULTIDRUG-RESISTANCE; 1,4-NAPHTHOQUINONE DERIVATIVES; CELL-GROWTH; DNA-DAMAGE; CYTOTOXICITY; INDUCTION; ANTIFUNGAL; EXPRESSION; VITAMIN-K3; APOPTOSIS;
D O I：
10.1517/13543776.2013.798303
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Introduction: A large number of natural products including several synthetic drugs possess naphthoquinone chromophore. Various methods have been devised for their synthesis. Several naphthoquinone derivatives have been found to possess diverse biological properties especially anticancer activity which has stimulated keen interest and research in this field. Areas covered: The present review provides recent therapeutic patent literature (2000 - 2012) describing the applications of naphthoquinones and their derivatives on anticancer activities. Information from articles published in international peer-reviewed journals has been included to comprise a more exhaustive review. Expert opinion: With the advent of stem cell research and molecular mechanism associated with cure of cancer, the use of classical and novel naphthoquinone structures have been more frequently noted in recent (2000 - 2012) patented agents for treatment of cancer.
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收藏
页码：1087 / 1108
页数：22
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