Stem cell function and maintenance - ends that matter: Role of telomeres and telomerase

被引：13
|
作者：
Saeed, Hamid [1 ]
Iqtedar, Mehwish [2 ]
机构：
[1] Stanford Univ, Sch Med, Dept Endocrinol, Stanford, CA 94305 USA
[2] Women Univ, Lahore Coll, Dept Biotechnol & Microbiol, Lahore, Pakistan
来源：
JOURNAL OF BIOSCIENCES | 2013年 / 38卷 / 03期
关键词：
Aging; stem cells; telomerase; telomeres; MARROW STROMAL CELLS; ACUTE MYELOID-LEUKEMIA; T-CELLS; OSTEOBLAST DIFFERENTIATION; NEURONAL DIFFERENTIATION; CHROMOSOMAL INSTABILITY; REPLICATIVE SENESCENCE; CATALYTIC SUBUNIT; HUMAN-LYMPHOCYTES; MOUSE TELOMERASE;
D O I：
10.1007/s12038-013-9346-3
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Stem cell research holds a promise to treat and prevent age-related degenerative changes in humans. Literature is replete with studies showing that stem cell function declines with aging, especially in highly proliferative tissues/organs. Among others, telomerase and telomere damage is one of the intrinsic physical instigators that drive age-related degenerative changes. In this review we provide brief overview of telomerase-deficient aging affects in diverse stem cells populations. Furthermore, potential disease phenotypes associated with telomerase dysregulation in a specific stem cell population is also discussed in this review. Additionally, the role of telomerase in stem cell driven cancer is also briefly touched upon.
引用
收藏
页码：641 / 649
页数：9
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