Stem cell function and maintenance - ends that matter: Role of telomeres and telomerase

被引：13

作者：

Saeed, Hamid ^{[1
]}

Iqtedar, Mehwish ^{[2
]}

机构：

[1] Stanford Univ, Sch Med, Dept Endocrinol, Stanford, CA 94305 USA

[2] Women Univ, Lahore Coll, Dept Biotechnol & Microbiol, Lahore, Pakistan

来源：

JOURNAL OF BIOSCIENCES | 2013年 / 38卷 / 03期

关键词：

Aging; stem cells; telomerase; telomeres; MARROW STROMAL CELLS; ACUTE MYELOID-LEUKEMIA; T-CELLS; OSTEOBLAST DIFFERENTIATION; NEURONAL DIFFERENTIATION; CHROMOSOMAL INSTABILITY; REPLICATIVE SENESCENCE; CATALYTIC SUBUNIT; HUMAN-LYMPHOCYTES; MOUSE TELOMERASE;

D O I：

10.1007/s12038-013-9346-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Stem cell research holds a promise to treat and prevent age-related degenerative changes in humans. Literature is replete with studies showing that stem cell function declines with aging, especially in highly proliferative tissues/organs. Among others, telomerase and telomere damage is one of the intrinsic physical instigators that drive age-related degenerative changes. In this review we provide brief overview of telomerase-deficient aging affects in diverse stem cells populations. Furthermore, potential disease phenotypes associated with telomerase dysregulation in a specific stem cell population is also discussed in this review. Additionally, the role of telomerase in stem cell driven cancer is also briefly touched upon.

引用

页码：641 / 649

页数：9

共 109 条

[1] Human mesenchymal stem cells: from basic biology to clinical applications [J].

Abdallah, B. M. ;

Kassem, M. .

GENE THERAPY, 2008, 15 (02) :109-116

[2] Inhibition of osteoblast differentiation but not adipocyte differentiation of mesenchymal stem cells by sera obtained from aged females [J].

Abdallah, Basem M. ;

Haack-Sorensen, Mandana ;

Fink, Trine ;

Kassem, Moustapha .

BONE, 2006, 39 (01) :181-188

[3] The Use of Mesenchymal (Skeletal) Stem Cells for Treatment of Degenerative Diseases: Current Status and Future Perspectives [J].

Abdallah, Basem M. ;

Kassem, Moustapha .

JOURNAL OF CELLULAR PHYSIOLOGY, 2009, 218 (01) :9-12

[4] mTert expression correlates with telomerase activity during the differentiation of murine embryonic stem cells [J].

Armstrong, L ;

Lako, M ;

Lincoln, J ;

Cairns, PM ;

Hole, N .

MECHANISMS OF DEVELOPMENT, 2000, 97 (1-2) :109-116

[5] Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice [J].

Artandi, SE ;

Chang, S ;

Lee, SL ;

Alson, S ;

Gottlieb, GJ ;

Chin, L ;

DePinho, RA .

NATURE, 2000, 406 (6796) :641-645

[6] Age-related cognitive decline: Can neural stem cells help us? [J].

Artegiani, Benedetta ;

Calegari, Federico .

AGING-US, 2012, 4 (03) :176-186

[7] Mitochondria, oxidants, and aging [J].

Balaban, RS ;

Nemoto, S ;

Finkel, T .

CELL, 2005, 120 (04) :483-495

[8] Adult bone marrow stem cells for cell and gene therapies: Implications for greater use [J].

Ballas, CB ;

Zielske, SP ;

Gerson, SL .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2002, :20-28

[9] Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion [J].

Baxter, MA ;

Wynn, RF ;

Jowitt, SN ;

Wraith, JE ;

Fairbairn, LJ ;

Bellantuono, I .

STEM CELLS, 2004, 22 (05) :675-682

[10]

Beausejour C, 2011, HDB EXPT PHARM, V180, P67

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