Low-molecular-weight, calcium-dependent phospholipase a, genes are linked and map to homologous chromosome regions in mouse and human

被引：91

作者：

Tischfield, JA

Xia, YR

Shih, DM

Klisak, I

Chen, J

Engle, SJ

Siakotos, AN

Winstead, MV

Seilhamer, JJ

Allamand, V

Gyapay, G

Lusis, AJ

机构：

[1] UNIV CALIF LOS ANGELES, DEPT MED, LOS ANGELES, CA 90095 USA

[2] UNIV CALIF LOS ANGELES, DEPT MICROBIOL & MOLEC GENET, LOS ANGELES, CA 90095 USA

[3] UNIV CALIF LOS ANGELES, INST MOLEC BIOL, LOS ANGELES, CA 90095 USA

[4] INCYTE PHARMACEUT INC, PALO ALTO, CA 94304 USA

[5] GENETHON, F-91000 EVRY, FRANCE

来源：

GENOMICS | 1996年 / 32卷 / 03期

关键词：

D O I：

10.1006/geno.1996.0126

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The Group IIA phospholipase gene (PLA2G2A) protein coding regions exhibit significant homology with recently described Group IIC (PLA2G2C) and Group V (PLA2GV) genes, All three genes are present in many mammalian species and are expressed in a tissue-specific pattern. Here, we demonstrate in human that they are tightly linked and map to chromosome 1p34-p36.1. We also show that the homologous mouse loci are tightly linked (no observed recombination) on the dis tal part of chromosome 4, a region exhibiting synteny with human 1p34-p36, Unlike its rodent counterpart, human PLA2G2C appears to be a nonfunctional pseudogene. (C) 1996 Academic Press, Inc.

引用

页码：328 / 333

页数：6

共 34 条

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