Nutritional interventions for autism spectrum disorder

被引:64
作者
Karhu, Elisa [1 ]
Zukerman, Ryan [1 ]
Eshraghi, Rebecca S. [2 ]
Mittal, Jeenu [1 ]
Deth, Richard C. [3 ]
Castejon, Ana M. [3 ]
Trivedi, Malav [3 ]
Mittal, Rahul [1 ]
Eshraghi, Adrien A. [1 ,4 ]
机构
[1] Univ Miami, Miller Sch Med, Dept Otolaryngol, Miami, FL 33136 USA
[2] Univ Miami, Miller Sch Med, Dept Med, Div Gastroenterol, Miami, FL 33136 USA
[3] Nova Southeastern Univ, Coll Pharm, Dept Pharmaceut Sci, Ft Lauderdale, FL 33314 USA
[4] Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami, FL 33136 USA
关键词
Autism spectrum disorder (ASD); gluten-free diet; casein-free diet; ketogenic diet; specific carbohydrate diet; probiotics; polyunsaturated fatty acids; dietary supplements; FATTY-ACID SUPPLEMENTATION; FREE/CASEIN-FREE DIET; CASEIN-FREE DIETS; GLUTEN-FREE DIET; KETOGENIC DIET; DOUBLE-BLIND; INTESTINAL BARRIER; MOUSE MODEL; DOCOSAHEXAENOIC ACID; GENE POLYMORPHISM;
D O I
10.1093/nutrit/nuz092
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Autism spectrum disorder (ASD) is an increasingly prevalent neurodevelopmental disorder with considerable clinical heterogeneity. With no cure for the disorder, treatments commonly center around speech and behavioral therapies to improve the characteristic social, behavioral, and communicative symptoms of ASD. Gastrointestinal disturbances are commonly encountered comorbidities that are thought to be not only another symptom of ASD but to also play an active role in modulating the expression of social and behavioral symptoms. Therefore, nutritional interventions are used by a majority of those with ASD both with and without clinical supervision to alleviate gastrointestinal and behavioral symptoms. Despite a considerable interest in dietary interventions, no consensus exists regarding optimal nutritional therapy. Thus, patients and physicians are left to choose from a myriad of dietary protocols. This review, summarizes the state of the current clinical and experimental literature on nutritional interventions for ASD, including gluten-free and casein-free, ketogenic, and specific carbohydrate diets, as well as probiotics, polyunsaturated fatty acids, and dietary supplements (vitamins A, C, B6, and B12; magnesium and folate).
引用
收藏
页码:515 / 531
页数:17
相关论文
共 50 条
[31]   Gluten and Autism Spectrum Disorder [J].
Croall, Iain D. ;
Hoggard, Nigel ;
Hadjivassiliou, Marios .
NUTRIENTS, 2021, 13 (02) :1-19
[32]   A Review on Autism Spectrum Disorder: Pathogenesis, Biomarkers, Pharmacological and Non-Pharmacological Interventions [J].
Majhi, Sagarika ;
Kumar, Sokindra ;
Singh, Lubhan .
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2023, 22 (05) :659-677
[33]   Autism Spectrum Disorder as a Brain-Gut-Microbiome Axis Disorder [J].
Saurman, Virginia ;
Margolis, Kara G. ;
Luna, Ruth Ann .
DIGESTIVE DISEASES AND SCIENCES, 2020, 65 (03) :818-828
[34]   Dietary Supplement for Core Symptoms of Autism Spectrum Disorder: Where Are We Now and Where Should We Go? [J].
Li, Yong-Jiang ;
Ou, Jian-Jun ;
Li, Ya-Min ;
Xiang, Da-Xiong .
FRONTIERS IN PSYCHIATRY, 2017, 8
[35]   Efficacy and Safety of Diet Therapies in Children With Autism Spectrum Disorder: A Systematic Literature Review and Meta-Analysis [J].
Yu, Yuping ;
Huang, Jinyue ;
Chen, Xiaofang ;
Fu, Jia ;
Wang, Xinhui ;
Pu, Linjie ;
Gu, Chunyu ;
Cai, Chunquan .
FRONTIERS IN NEUROLOGY, 2022, 13
[36]   Autism spectrum disorder (ASD) - An analysis of the ASD interventions utilized in Bangladesh [J].
Rahman, Tasmia ;
Hasan, Md Zobaer .
RESEARCH IN DEVELOPMENTAL DISABILITIES, 2025, 160
[37]   Efficacy and Safety of Risperidone Interventions in Children and Adolescents with Autism Spectrum Disorder [J].
Yang, Fei ;
Kang, Lin ;
Zou, Chaojie .
PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, 2025, 35 (02) :177-184
[38]   The Role of Lipidomics in Autism Spectrum Disorder [J].
El-Ansary, Afaf ;
Chirumbolo, Salvatore ;
Bhat, Ramesa Shafi ;
Dadar, Maryam ;
Ibrahim, Eiman M. ;
Bjorklund, Geir .
MOLECULAR DIAGNOSIS & THERAPY, 2020, 24 (01) :31-48
[39]   Autism Spectrum Disorder [J].
Long, Melissa ;
Register-Brown, Kelly .
PEDIATRICS IN REVIEW, 2021, 42 (07) :360-374
[40]   Potential Role of L-Carnitine in Autism Spectrum Disorder [J].
Kepka, Alina ;
Ochocinska, Agnieszka ;
Chojnowska, Sylwia ;
Borzym-Kluczyk, Malgorzata ;
Skorupa, Ewa ;
Knas, Malgorzata ;
Waszkiewicz, Napoleon .
JOURNAL OF CLINICAL MEDICINE, 2021, 10 (06) :1-26